PHARMACOKINETICS OF ALPRAZOLAM IN GERIATRIC-PATIENTS WITH NEUROTIC DEPRESSION

被引：6

作者：

DEHLIN, O

KULLINGSJO, H

LIDEN, A

AGRELL, B

MOSER, G

OLSEN, I

机构：

[1] ST LARS HOSP,DEPT PSYCHIAT & NEUROCHEM,S-22006 LUND,SWEDEN

[2] UPJOHN CO,GOTHENBURG,SWEDEN

[3] VARNHEMS HOSP,GERIATR CLIN,MALMO,SWEDEN

来源：

PHARMACOLOGY & TOXICOLOGY | 1991年 / 68卷 / 02期

关键词：

D O I：

10.1111/j.1600-0773.1991.tb02048.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacokinetics of alprazolam was studied in 10 geriatric patients (5 males, 5 females) with neurotic depression during a 6-week period. After 0.5 mg of alprazolam on Day 1 the mean elimination half-life was 11.1 hr and C(max) 12.3 ng/ml. The pharmacokinetic evaluation on Day 1 (t 1/2, tmax) did not differ significantly from the evaluation on Day 42. The mean daily dosage on Day 42 was 1.6 mg alprazolam. The concentrations of the metabolites alpha-OH alprazolam and 4-OH alprazolam were less than 10% of that of alprazolam. All the patients improved clinically. The most common side effect was drowsiness, more often during the first week than the last week.

引用

页码：121 / 124

页数：4

共 13 条

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