SCHOTTEN-BAUMANN ACYLATION OF N-DEBENZOYLTAXOL - AN EFFICIENT ROUTE TO N-ACYL TAXOL ANALOGS AND THEIR BIOLOGICAL EVALUATION

被引：51

作者：

GEORG, GI ^{[1
]}

BOGE, TC ^{[1
]}

CHERUVALLATH, ZS ^{[1
]}

HARRIMAN, GCB ^{[1
]}

HEPPERLE, M ^{[1
]}

PARK, H ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT BIOCHEM,LAWRENCE,KS 66045

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80139-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient route to N-acyl taxol analogues is described utilizing N-debenzoyltarol (II). Acylation of 11 with various acid chlorides under Schotten-Baumann conditions led to a facile one step synthesis of several N-acyl taxol analogues from a common intermediate.

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页码：335 / 338

页数：4

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