UV-INDUCED MUTABILITY IN REPAIR-DEFICIENT RAD6-1 STRAINS OF SACCHAROMYCES-CEREVISIAE IS CAUSED BY A SUPPRESSOR GENE

被引：5
|
作者：
VLCKOVA, V [1 ]
ZUFFOVA, Z [1 ]
BROZMANOVA, J [1 ]
机构：
[1] SLOVAK ACAD SCI, CANC RES INST, DEPT MOLEC GENET, CS-81232 BRATISLAVA, CZECHOSLOVAKIA
来源：
FOLIA MICROBIOLOGICA | 1992年 / 37卷 / 04期
关键词：
D O I：
10.1007/BF02814561
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The RAD6 gene is a multifunctional gene required for DNA repair, induced mutagenesis and sporulation. The survival and revertibility of two loci in four rad6-1 mutant strains of different origin after UV irradiation were followed. As expected, all the rad6-1 strains tested were more sensitive to UV radiation in comparison with RAD6 strains. The reversion frequency per survivor in trp1-289 and arg4-17 alleles was significantly higher in all four rad6-1 mutant strains than in wild-type strains after equal doses of UV radiation. On the basis of genetic analysis we suggest that the phenomenon of increased frequency of induced mutagenesis is caused by a suppressor gene.
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页码：267 / 272
页数：6
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