7-ALKOXYQUINOLINE O-DEALKYLATION BY MICROSOMES FROM HUMAN LIVER AND PLACENTA

被引：6

作者：

HAKKOLA, J

MAENPAA, J

MAYER, RT

PARK, SS

GELBOIN, HV

PELKONEN, O

机构：

[1] UNIV OULU,DEPT PHARMACOL & TOXICOL,SF-90220 OULU,FINLAND

[2] NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20892

[3] USDA ARS,US HORT RES LAB,ORLANDO,FL 32803

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 34卷 / 05期

关键词：

7-ALKOXYQUINOLINE; CYTOCHROME P450; HUMAN LIVER; HUMAN PLACENTA; CIGARETTE SMOKING;

D O I：

10.1111/j.1365-2125.1992.tb05650.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The O-dealkylation of seven 7-alkoxyquinoline derivatives by human hepatic and placental microsomes and the effect of maternal cigarette smoking on placental 7-alkoxyquinoline metabolism was studied. 2 None of several monoclonal antibodies to isoenzymes of cytochrome P450 had a clear effect on metabolism of the compounds by liver microsomes. 3 Maternal cigarette smoking induced the O-dealkylation of all of the 7-alkoxyquinoline derivatives, being greatest for 7-butoxy- and 7-benzyloxyquinoline. 4 Placental 7-alkoxyquinoline metabolism induced by smoking was partially inhibited by the monoclonal antibody 1-7-1 raised against 3-methylcholanthrene-induced rat liver P450. 5 None of the 7-alkoxyquinoline O-dealkylations could be assigned specifically to any known P450 isoenzyme in human liver or placenta.

引用

页码：415 / 420

页数：6

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