INCREASED LEVELS OF C-FOS AND C-MYC MESSENGER-RNA IN ATP-STIMULATED ENDOTHELIAL-CELLS

被引：19

作者：

BOUTHERINFALSON, O

REUSE, S

DUMONT, JE

BOEYNAEMS, JM

机构：

[1] Institute of Interdisciplinary Research, Université Libre de Brussels, B-1070 Brussels, Campus Erasme

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80210-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In bovine aortic endothelial cells, ATP induced a transient and sequential accumulation of c-fos and c-myc mRNA, which was detected after 1 hour and 3 hours, respectively. The effect of ATP on c-fos mRNA was stronger than that of TNF and bFGF. Both ATP and bFGF increased c-myc mRNA after a 3 hour treatment, whereas TNF did not. If none of the 3 agonists tested induced a selective expression of c-fos or c-myc, each of them was associated with a different quantitative combination of the 2 signals, which might be related to the distinct responses that they trigger in endothelial cells. © 1990 Academic Press, Inc.

引用

页码：306 / 312

页数：7

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