Donor V delta 1(+) gamma delta T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL

被引：0

作者：

Prinz, Immo ^{[1
]}

Thamm, Kristina ^{[1
]}

Port, Matthias ^{[2
]}

Weissinger, Eva M. ^{[2
]}

Stadler, Michael ^{[2
]}

Gabaev, Ildar ^{[3
]}

Jacobs, Roland ^{[4
]}

Ganser, Arnold ^{[2
]}

Koenecke, Christian ^{[1
,2
]}

机构：

[1] Hannover Med Sch, Inst Immunol, Hannover, Germany

[2] Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, Hannover, Germany

[3] Hannover Med Sch, Inst Virol, Hannover, Germany

[4] Hannover Med Sch, Dept Clin Immunol & Rheumatol, Hannover, Germany

来源：

EXPERIMENTAL HEMATOLGY & ONCOLOGY | 2013年 / 2卷

关键词：

B-CLL; V delta 1(+) T lymphocytes; CMV reactivation; Allogeneic stem cell transplantation;

D O I：

10.1186/2162-3619-2-14

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

gamma delta T lymphocytes play an important role in immune reactions towards infections and malignancies. In particular, V gamma 9(-) V delta 1(+) T lymphocytes are thought to play protective antiviral roles in human CMV infection. Recently, V delta 1(+) T lymphocytes were proposed to also have anti-B-CLL reactivity. Here we report a case of 48-year-old man who received allogeneic stem cell transplantation for progressive B-CLL. Within one year after transplantation, lymphoma relapsed despite a dramatic increase of V delta 1(+) T cells in the patient's blood. In vitro killing assays revealed activity of patient's gamma delta cells against CMV target cells, but not against the relapsing lymphoma-cells. This argues for a contribution of V delta 1(+) cells in the immune reaction against CMV reactivation, but does not support a strong correlation of expanded V delta 1(+) T cells and favorable disease outcome in B-CLL patients.

引用

页数：4

共 50 条

[1] Donor Vδ1+ γδ T cells expand after allogeneic hematopoietic stem cell transplantation and show reactivity against CMV-infected cells but not against progressing B-CLL
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