CARDIOVASCULAR EFFECTS OF DIFFERENT SCHEDULES OF NICOTINE ADMINISTRATION ON SPINAL RATS - INFLUENCE OF PENTOBARBITAL

被引：2

作者：

CRUZ, SL ^{[1
]}

FERNANDEZGUASTI, A ^{[1
]}

VILLARREAL, JE ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, DEPT FARMACOL, MEXICO CITY, MEXICO

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 258卷 / 1-2期

关键词：

NICOTINE; CARDIOVASCULAR EFFECT; BLOOD PRESSURE; HEART RATE; PENTOBARBITAL; TACHYPHYLAXIS;

D O I：

10.1016/0014-2999(94)90055-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This work examined the cardiovascular effects of different schedules of i.v. nicotine administration with respect to doses and timing in non-anesthetized and pentobarbital-treated spinal rats. For this purpose, complete nicotine dose-response curves were made for mean arterial pressure and heart rate. In non-anesthetized spinal rats, tachyphylaxis was not found for the presser effects; moreover, consecutive doses, given at short intervals, produced additive actions. Furthermore, nicotine produced a biphasic heart rate response: an initial and brief bradycardia followed by a longer lasting tachycardia. In pentobarbital-treated rats, the sensitivity of the cardiovascular system to nicotine was decreased; in these rats, consecutive nicotine doses did show tachyphylaxis for the presser and tachycardiac responses. The present series of experiments, using different schedules of administration for single and consecutive nicotine doses, demonstrated opposite tachyphylactic effects in non-anesthetized and in pentobarbital-treated spinal rats.

引用

页码：39 / 45

页数：7

共 38 条

[11] NOREPINEPHRINE AND EPINEPHRINE RELEASE AND ADRENERGIC MEDIATION OF SMOKING-ASSOCIATED HEMODYNAMIC AND METABOLIC EVENTS [J].

CRYER, PE ;

HAYMOND, MW ;

SANTIAGO, JV ;

SHAH, SD .

NEW ENGLAND JOURNAL OF MEDICINE, 1976, 295 (11) :573-577

[12]

Dale HH, 1914, J PHARMACOL EXP THER, V6, P147

[13]

DOMIGAN NM, 1984, P U OTAGO MED SCH, V62, P76

[14]

DOMINO EF, 1967, ANN NY ACAD SCI, V142, P217

[15] DESENSITIZATION OF CENTRAL NICOTINIC CARDIOVASCULAR EFFECTS BY NICOTINE ISOMERS AND A QUATERNARY ANALOG [J].

DONG, L ;

HOUDI, AA ;

VANLOON, GR .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 38 (04) :843-852

[16] MOLECULAR SITES OF ANESTHETIC ACTION IN POSTSYNAPTIC NICOTINIC MEMBRANES [J].

FORMAN, SA ;

MILLER, KW .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (11) :447-452

[17] MEMBERS OF A NICOTINIC ACETYLCHOLINE-RECEPTOR GENE FAMILY ARE EXPRESSED IN DIFFERENT REGIONS OF THE MAMMALIAN CENTRAL-NERVOUS-SYSTEM [J].

GOLDMAN, D ;

DENERIS, E ;

LUYTEN, W ;

KOCHHAR, A ;

PATRICK, J ;

HEINEMANN, S .

CELL, 1987, 48 (06) :965-973

[18] CIGARETTE-SMOKING AND THE ADRENERGIC NERVOUS-SYSTEM [J].

GRASSI, G ;

SERAVALLE, G ;

CALHOUN, DA ;

BOLLA, G ;

MANCIA, G .

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1992, 14 (1-2) :251-260

[19] BLOOD-PRESSURE IN SMOKERS AND NONSMOKERS - EPIDEMIOLOGIC FINDINGS [J].

GREEN, MS ;

JUCHA, E ;

LUZ, Y .

AMERICAN HEART JOURNAL, 1986, 111 (05) :932-940

[20] PERSISTENT BLOOD-PRESSURE INCREASE INDUCED BY HEAVY SMOKING [J].

GROPPELLI, A ;

GIORGI, DMA ;

OMBONI, S ;

PARATI, G ;

MANCIA, G .

JOURNAL OF HYPERTENSION, 1992, 10 (05) :495-499

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