FUSED PYRIMIDINES - SYNTHESIS OF PYRAZOLO[3,4-E][1,3,4]THIADIAZOLO[3,2-A]PYRIMIDINE AND PYRAZOLO[4',3'-5,6]PYRIMIDO[2,1-B]BENZOTHIAZOLE DERIVATIVES

被引：0

作者：

ELASHMAWY, MB ^{[1
]}

SHEHATA, IA ^{[1
]}

ELSUBBAGH, HI ^{[1
]}

ELEMAM, AA ^{[1
]}

机构：

[1] UNIV MANSOURA,FAC PHARM,DEPT MED CHEM,MANSOURA,EGYPT

来源：

GAZZETTA CHIMICA ITALIANA | 1991年 / 121卷 / 03期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of 2-amino-5-methyl-1,3,4-thiadiazole, 1, 2-amino-6-methylbenzothiazole, 7, or 3-amino-5-methylisoxazole, 12, with diethyl ethoxymethylenemalonate yielded the corresponding diethyl 2-substituted aminomethylenemalonates 3, 8 and 13, which were cyclized by the action of polyphosphoric acid to the corresponding fused pyrimidine derivatives 4, 9 and 14. Hydrazinolysis of 4 and 9 yielded the tricyclic and tetracyclic derivatives 5 and 10, respectively.

引用

页码：113 / 115

页数：3

共 23 条

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