PROLIFERATION OF HUMAN SMOOTH-MUSCLE CELLS PROMOTED BY LIPOPROTEIN(A)

被引：365
作者：
GRAINGER, DJ
KIRSCHENLOHR, HL
METCALFE, JC
WEISSBERG, PL
WADE, DP
LAWN, RM
机构：
[1] STANFORD UNIV,SCH MED,DIV CARDIOVASC MED,STANFORD,CA 94305
[2] UNIV CAMBRIDGE,DEPT BIOCHEM,CAMBRIDGE CB2 1QW,ENGLAND
[3] UNIV CAMBRIDGE,SCH CLIN MED,CAMBRIDGE CB2 2QQ,ENGLAND
来源：
SCIENCE | 1993年 / 260卷 / 5114期
基金：
英国惠康基金;
关键词：
D O I：
10.1126/science.8503012
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Elevated blood concentrations of lipoprotein(a) [Lp(a)] and its constituent, apolipoprotein(a) [apo(a)], constitute a major risk factor for atherosclerosis, but their physiological activities remain obscure. Lp(a) and purified apo(a) stimulated the growth of human smooth muscle cells in culture. This effect resulted from inhibition of plasminogen activation, and consequently the activation by plasmin of latent transforming growth factor-beta, which is an inhibitor of smooth muscle cell growth. Because smooth muscle proliferation is one of the hallmarks of atherosclerotic lesions, these results point to a plausible mechanism for the atherogenic activity of Lp(a).
引用
收藏
页码：1655 / 1658
页数：4
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