HEPATOCYTE GROWTH-FACTOR HAS POTENT ANTIPROLIFERATIVE ACTIVITY IN VARIOUS TUMOR-CELL LINES

被引：232

作者：

TAJIMA, H ^{[1
]}

MATSUMOTO, K ^{[1
]}

NAKAMURA, T ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN

来源：

FEBS LETTERS | 1991年 / 291卷 / 02期

关键词：

HEPATOCYTE GROWTH FACTOR (HGF); ANTITUMOR AGENT; GROWTH INHIBITION; HGF RECEPTOR;

D O I：

10.1016/0014-5793(91)81291-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocyte growth factor (HGF) has potent mitogenic activity for mature hepatocytes and various normal epithelial cells. We now have evidence that HGF at 1-10 ng/ml, strongly inhibits the growth of HepG2 hepatocellular carcinoma cells, B6/F1 melanoma cells and KB squamous carcinoma cells. These tumor cells express high affinity receptors for HGF with a K(d) of 25-28 pM, similar to findings with hepatocytes. HGF at 1-100 ng/ml had no significant cytolytic effect on tumor cells. Therefore, the anti-proliferative effect of HGF on tumor cells seems to be cytostatic, not cytolytic. As HGF apparently has bidirectional effects on cell growth, the possibility that it can serve as an anti-tumor agent merits attention.

引用

页码：229 / 232

页数：4

共 22 条

[1]

ASAMI O, 1991, J BIOCHEM-TOKYO, V109, P8

[2] IDENTIFICATION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR AS THE C-MET PROTOONCOGENE PRODUCT [J].