COORDINATE EXPRESSION OF C-FOS, P53 AND CYTOKERATIN GENES DURING THE ALTERATION OF GROWTH OF HUMAN HEPATOMA-CELLS - MESSENGER-RNA LEVELS MEASURED BY REVERSE TRANSCRIPTION AND POLYMERASE CHAIN-REACTION

被引：7

作者：

KANEKO, Y

TSUKAMOTO, A

KOROKAWA, K

机构：

[1] First Department of Medicine, The University of Tokyo, Faculty of Medicine, Bunkyo-ku, Tokyo, 113, 7-3-1, Hongo

来源：

CANCER LETTERS | 1992年 / 66卷 / 02期

关键词：

TUMOR PROMOTER; ONCOGENE; ANTIONCOGENE; CYTOKERATIN; POLYMERASE CHAIN REACTION; HEPATOMA;

D O I：

10.1016/0304-3835(92)90228-N

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Teleocidin, a tumor promoter, inhibited the proliferation, enhanced cytokeratin assembly and increased the type III procollagen production of PLC/PRF/5 hepatoma cells. Teleocidin transiently increased the levels of c-fos and p53 mRNAs measured by reverse transcription and polymerase chain reaction. This was followed by a reduction of c-myc mRNA and an increase of cytokeratin mRNA. The level of p120 mRNA was not remarkably altered. Sequential alterations of the expression of c-fos, p53, c-myc and cytokeratin genes induced by teleocidin may be responsible for the morphological and functional changes of hepatoma cells induced by this tumor promoter.

引用

页码：155 / 164

页数：10

共 40 条

[21] DIFFERENTIATION OF F9 TERATOCARCINOMA STEM-CELLS AFTER TRANSFER OF C-FOS PROTO-ONCOGENES [J].

MULLER, R ;

WAGNER, EF .

NATURE, 1984, 311 (5985) :438-442

[22] THE MOLECULAR HETEROGENEITY OF PROTEIN KINASE-C AND ITS IMPLICATIONS FOR CELLULAR-REGULATION [J].

NISHIZUKA, Y .

NATURE, 1988, 334 (6184) :661-665

[23]

PFEIFER U, 1988, VIRCHOWS ARCH B, V55, P363

[24] IMMUNOCHEMICAL APPROACHES TO DNA-STRUCTURE INVESTIGATION .1. IMMUNOCHEMICAL IDENTIFICATION OF THE PRODUCT OF CYTOSINE MODIFICATION WITH BISULFITE AND O-METHYLHYDROXYLAMINE MIXTURE [J].

POVERENNY, AM ;

PODGORODNICHENKO, VK ;

BRYKSINA, LE ;

MONASTYRSKAYA, GS ;

SVERDLOV, ED .

MOLECULAR IMMUNOLOGY, 1979, 16 (05) :313-316

[25] PRIMER-DIRECTED ENZYMATIC AMPLIFICATION OF DNA WITH A THERMOSTABLE DNA-POLYMERASE [J].

SAIKI, RK ;

GELFAND, DH ;

STOFFEL, S ;

SCHARF, SJ ;

HIGUCHI, R ;

HORN, GT ;

MULLIS, KB ;

ERLICH, HA .

SCIENCE, 1988, 239 (4839) :487-491

[26] IMMUNOLOCALIZATION OF TYPE-III COLLAGEN AND PROCOLLAGEN IN CIRRHOTIC HUMAN-LIVER USING MONOCLONAL-ANTIBODIES [J].

SAKAKIBARA, K ;

OOSHIMA, A ;

IGARASHI, S ;

SAKAKIBARA, J .

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1986, 409 (01) :37-46

[27]

SCHWAB M, 1990, Critical Reviews in Oncogenesis, V2, P35

[28] MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS [J].

STEINERT, PM ;

ROOP, DR .

ANNUAL REVIEW OF BIOCHEMISTRY, 1988, 57 :593-625

[29] REDUCED INDUCTION OF C-FOS BUT NOT OF C-MYC EXPRESSIONS IN A NONTUMORIGENIC REVERTANT R1 OF EJ-RAS-TRANSFORMED NIH/3T3 CELLS TREATED WITH 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA) [J].

SUZUKI, H ;

FUJITA, H ;

OGISO, Y ;

ODA, A ;

KUZUMAKI, N ;

UCHINO, J .

EXPERIMENTAL CELL RESEARCH, 1989, 184 (02) :524-528

[30] REGULATION OF PROTEIN-TURNOVER VERSUS GROWTH-STATE - STUDIES ON THE MECHANISM(S) OF INITIATION OF ACIDIC VACUOLAR PROTEOLYSIS IN CELLS OF STATIONARY ASCITES HEPATOMA [J].

TESSITORE, L ;

BONELLI, G ;

CECCHINI, G ;

AUTELLI, R ;

AMENTA, JS ;

BACCINO, FM .

BIOCHEMICAL JOURNAL, 1988, 251 (02) :483-490

← 1 2 3 4 →