Error-rate degradation due to fiber four-wave mixing in a four-channel FSK direct detection system is observed with an equal input power per channel into a dispersion-shifted fiber. The power penalty is different with and without modulating the other channels. Comparing this difference in our system with that in a previously reported FSK-AMI heterodyne system, we find that the influence of four-wave mixing on error rate is dependent on the demodulation scheme. The degradation in a 100-channel FSK direct-detection system is also estimated based on the result obtained here.