6-METHYLENANDROSTA-1,4-DIENE-3,17-DIONE (FCE 24304) - A NEW IRREVERSIBLE AROMATASE INHIBITOR

被引：126
作者：
GIUDICI, D [1 ]
ORNATI, G [1 ]
BRIATICO, G [1 ]
BUZZETTI, F [1 ]
LOMBARDI, P [1 ]
DISALLE, E [1 ]
机构：
[1] FARMITALIA C ERBA,RES & DEV ONCOL,VIA GIOVANNI 23,I-20014 NERVIANO,ITALY
来源：
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1988年 / 30卷 / 1-6期
关键词：
D O I：
10.1016/0022-4731(88)90129-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：391 / 394
页数：4
相关论文
共 13 条
  • [1] INACTIVATION OF AROMATASE INVITRO BY 4-HYDROXY-4-ANDROSTENE-3, 17-DIONE AND 4-ACETOXY-4-ANDROSTENE-3, 17-DIONE AND SUSTAINED EFFECTS INVIVO
    BRODIE, AMH
    GARRETT, WM
    HENDRICKSON, JR
    TSAIMORRIS, CH
    MARCOTTE, PA
    ROBINSON, CH
    [J]. STEROIDS, 1981, 38 (06) : 693 - 702
  • [2] COVEY DF, 1982, CANCER RES, V42, P3327
  • [3] ENZYME-GENERATED INTERMEDIATES DERIVED FROM 4-ANDROSTENE-3,6,17-TRIONE AND 1,4,6-ANDROSTATRIENE-3,17-DIONE CAUSE A TIME-DEPENDENT DECREASE IN HUMAN PLACENTAL AROMATASE-ACTIVITY
    COVEY, DF
    HOOD, WF
    [J]. ENDOCRINOLOGY, 1981, 108 (04) : 1597 - 1599
  • [4] 1-METHYL-1,4-ANDROSTADIENE-3,17-DIONE (SH 489) - CHARACTERIZATION OF AN IRREVERSIBLE INHIBITOR OF ESTROGEN BIOSYNTHESIS
    HENDERSON, D
    NORBISRATH, G
    KERB, U
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1986, 24 (01) : 303 - 306
  • [5] BIOCHEMICAL AND ENDOCRINE PROPERTIES OF A MECHANISM-BASED INHIBITOR OF AROMATASE
    JOHNSTON, JO
    WRIGHT, CL
    METCALF, BW
    [J]. ENDOCRINOLOGY, 1984, 115 (02) : 776 - 785
  • [6] KITZ R, 1962, J BIOL CHEM, V237, P3245
  • [7] BINDING OF A 4-METHYL-4-AZA-STEROID TO 5-ALPHA-REDUCTASE OF RAT-LIVER AND PROSTATE MICROSOMES
    LIANG, T
    HEISS, CE
    OSTROVE, S
    RASMUSSON, GH
    CHEUNG, A
    [J]. ENDOCRINOLOGY, 1983, 112 (04) : 1460 - 1468
  • [8] LOWRY OH, 1951, J BIOL CHEM, V193, P265
  • [9] PROSTATIC-CANCER .2. INHIBITORS OF RAT PROSTATIC 4-ENE-3-KETOSTEROID 5-ALPHA-REDUCTASE DERIVED FROM 6-METHYLENE-4-ANDROSTEN-3-ONES
    PETROW, V
    WANG, YS
    LACK, L
    SANDBERG, A
    KADOHAMA, N
    KENDLE, K
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1983, 19 (04) : 1491 - 1502
  • [10] SCREENING FOR ANTI-HORMONES BY RECEPTOR STUDIES
    RAYNAUD, JP
    BONNE, C
    BOUTON, MM
    MOGUILEWSKY, M
    PHILIBERT, D
    AZADIANBOULANGER, G
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1975, 6 (05) : 615 - 622
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