Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction

被引:94
作者
Ciavattini, Andrea [1 ]
Di Giuseppe, Jacopo [1 ]
Stortoni, Piergiorgio [1 ]
Montik, Nina [1 ]
Giannubilo, Stefano R. [1 ]
Litta, Pietro [2 ]
Islam, Md Soriful [3 ]
Tranquilli, Andrea L. [1 ]
Reis, Fernando M. [4 ,5 ]
Ciarmela, Pasquapina [3 ]
机构
[1] Polytech Univ Marche, Womans Hlth Sci Dept, Fac Med, Via Corridoni 11, I-60123 Ancona, Italy
[2] Univ Padua, Dept Gynaecol Sci & Human Reprod, I-35128 Padua, Italy
[3] Polytech Univ Marche, Dept Expt & Clin Med, Fac Med, I-60126 Ancona, Italy
[4] Univ Fed Minas Gerais, Dept Obstet & Gynecol, BR-30130100 Belo Horizonte, MG, Brazil
[5] Natl Inst Hormones & Womens Hlth, BR-30130100 Belo Horizonte, MG, Brazil
关键词
D O I
10.1155/2013/173184
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Uterine leiomyomas (fibroids or myomas) are benign tumors of uterus and clinically apparent in a large part of reproductive aged women. Clinically, they present with a variety of symptoms: excessive menstrual bleeding, dysmenorrhoea and intermenstrual bleeding, chronic pelvic pain, and pressure symptoms such as a sensation of bloatedness, increased urinary frequency, and bowel disturbance. In addition, they may compromise reproductive functions, possibly contributing to subfertility, early pregnancy loss, and later pregnancy complications. Despite the prevalence of this condition, myoma research is underfunded compared to other nonmalignant diseases. To date, several pathogenetic factors such as genetics, microRNA, steroids, growth factors, cytokines, chemokines, and extracellular matrix components have been implicated in the development and growth of leiomyoma. This paper summarizes the available literature regarding the ultimate relative knowledge on pathogenesis of uterine fibroids and their interactions with endometrium and subendometrial myometrium.
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页数:11
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共 154 条
  • [61] 2 DISTINCT ESTROGEN-REGULATED PROMOTERS GENERATE TRANSCRIPTS ENCODING THE 2 FUNCTIONALLY DIFFERENT HUMAN PROGESTERONE-RECEPTOR FORM-A AND FORM-B
    KASTNER, P
    KRUST, A
    TURCOTTE, B
    STROPP, U
    TORA, L
    GRONEMEYER, H
    CHAMBON, P
    [J]. EMBO JOURNAL, 1990, 9 (05) : 1603 - 1614
  • [62] The role of progesterone signaling in the pathogenesis of uterine leiomyoma
    Kim, J. Julie
    Sefton, Elizabeth C.
    [J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 358 (02) : 223 - 231
  • [63] Mediator is a transducer of Wnt/β-catenin signaling
    Kim, Seokjoong
    Xu, Xuan
    Hecht, Andreas
    Boyer, Thomas G.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (20) : 14066 - 14075
  • [64] Kjerulff KH, 1996, J REPROD MED, V41, P483
  • [65] Kogan E A, 2005, Arkh Patol, V67, P34
  • [66] Comparative analysis of cyclin D1 and oestrogen receptor (α and β) levels in human leiomyoma and adjacent myometrium
    Kovács, KA
    Oszter, A
    Göcze, PM
    Környei, JL
    Szabó, I
    [J]. MOLECULAR HUMAN REPRODUCTION, 2001, 7 (11) : 1085 - 1091
  • [67] Tumor necrosis factor-α expression in human uterine leiomyoma and its down-regulation by progesterone
    Kurachi, O
    Matsuo, H
    Samoto, T
    Maruo, T
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (05) : 2275 - 2280
  • [68] New Directions in the Epidemiology of Uterine Fibroids
    Laughlin, Shannon K.
    Schroeder, Jane C.
    Baird, Donna Day
    [J]. SEMINARS IN REPRODUCTIVE MEDICINE, 2010, 28 (03) : 203 - 216
  • [69] Bmp2 is critical for the murine uterine decidual response
    Lee, Kevin Y.
    Jeong, Jae-Wook
    Wang, Jinrong
    Ma, Lijiang
    Martin, James F.
    Tsai, Sophia Y.
    Lydon, John P.
    DeMayo, Francesco J.
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (15) : 5468 - 5478
  • [70] A new hypothesis about the origin of uterine fibroids based on gene expression profiting with microarrays
    Leppert, Phyllis C.
    Catherino, William H.
    Segars, James H.
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2006, 195 (02) : 415 - 420