Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction

被引:97
作者
Ciavattini, Andrea [1 ]
Di Giuseppe, Jacopo [1 ]
Stortoni, Piergiorgio [1 ]
Montik, Nina [1 ]
Giannubilo, Stefano R. [1 ]
Litta, Pietro [2 ]
Islam, Md Soriful [3 ]
Tranquilli, Andrea L. [1 ]
Reis, Fernando M. [4 ,5 ]
Ciarmela, Pasquapina [3 ]
机构
[1] Polytech Univ Marche, Womans Hlth Sci Dept, Fac Med, Via Corridoni 11, I-60123 Ancona, Italy
[2] Univ Padua, Dept Gynaecol Sci & Human Reprod, I-35128 Padua, Italy
[3] Polytech Univ Marche, Dept Expt & Clin Med, Fac Med, I-60126 Ancona, Italy
[4] Univ Fed Minas Gerais, Dept Obstet & Gynecol, BR-30130100 Belo Horizonte, MG, Brazil
[5] Natl Inst Hormones & Womens Hlth, BR-30130100 Belo Horizonte, MG, Brazil
关键词
D O I
10.1155/2013/173184
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Uterine leiomyomas (fibroids or myomas) are benign tumors of uterus and clinically apparent in a large part of reproductive aged women. Clinically, they present with a variety of symptoms: excessive menstrual bleeding, dysmenorrhoea and intermenstrual bleeding, chronic pelvic pain, and pressure symptoms such as a sensation of bloatedness, increased urinary frequency, and bowel disturbance. In addition, they may compromise reproductive functions, possibly contributing to subfertility, early pregnancy loss, and later pregnancy complications. Despite the prevalence of this condition, myoma research is underfunded compared to other nonmalignant diseases. To date, several pathogenetic factors such as genetics, microRNA, steroids, growth factors, cytokines, chemokines, and extracellular matrix components have been implicated in the development and growth of leiomyoma. This paper summarizes the available literature regarding the ultimate relative knowledge on pathogenesis of uterine fibroids and their interactions with endometrium and subendometrial myometrium.
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页数:11
相关论文
共 154 条
[21]   Myometrial zonal differentiation and uterine junctional zone hyperplasia in the non-pregnant uterus [J].
Brosens, JJ ;
Barker, FG ;
deSouza, NM .
HUMAN REPRODUCTION UPDATE, 1998, 4 (05) :496-502
[22]   Chemokines in hematopoiesis [J].
Broxmeyer, Hal E. .
CURRENT OPINION IN HEMATOLOGY, 2008, 15 (01) :49-58
[23]   The role of leiomyomas in infertility [J].
Bulletti, C ;
De Ziegler, D ;
Polli, V ;
Flamigni, C .
JOURNAL OF THE AMERICAN ASSOCIATION OF GYNECOLOGIC LAPAROSCOPISTS, 1999, 6 (04) :441-445
[24]  
BUTTRAM VC, 1981, FERTIL STERIL, V36, P433
[25]   A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids [J].
Cha, Pei-Chieng ;
Takahashi, Atsushi ;
Hosono, Naoya ;
Low, Siew-Kee ;
Kamatani, Naoyuki ;
Kubo, Michiaki ;
Nakamura, Yusuke .
NATURE GENETICS, 2011, 43 (05) :447-+
[26]   Diet and uterine myomas [J].
Chiaffarino, F ;
Parazzini, F ;
La Vecchia, C ;
Chatenoud, L ;
Di Cintio, E ;
Marsico, S .
OBSTETRICS AND GYNECOLOGY, 1999, 94 (03) :395-398
[27]   Activin-A in myometrium: Characterization of the actions on myometrial cells [J].
Ciarmela, Pasquapina ;
Wiater, Ezra ;
Vale, Wylie .
ENDOCRINOLOGY, 2008, 149 (05) :2506-2516
[28]   Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications [J].
Ciarmela, Pasquapina ;
Islam, Md. Soriful ;
Reis, Fernando M. ;
Gray, Peter C. ;
Bloise, Enrrico ;
Petraglia, Felice ;
Vale, Wylie ;
Castellucci, Mario .
HUMAN REPRODUCTION UPDATE, 2011, 17 (06) :772-790
[29]   Activin-A and Myostatin Response and Steroid Regulation in Human Myometrium: Disruption of Their Signalling in Uterine Fibroid [J].
Ciarmela, Pasquapina ;
Bloise, Enrrico ;
Gray, Peter C. ;
Carrarelli, Patrizia ;
Islam, Md. Soriful ;
De Pascalis, Flavio ;
Severi, Filiberto Maria ;
Vale, Wylie ;
Castellucci, Mario ;
Petraglia, Felice .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (03) :755-765
[30]   Presence, Actions, and Regulation of Myostatin in Rat Uterus and Myometrial Cells [J].
Ciarmela, Pasquapina ;
Wiater, Ezra ;
Smith, Sean M. ;
Vale, Wylie .
ENDOCRINOLOGY, 2009, 150 (02) :906-914