Utility of Procalcitonin in the Management of Hospital-Acquired Pneumonia - A Review

被引：0
作者：
Kumar, Sandeep [1 ]
Jan, Rafi Ahmed [1 ]
Rasool, Roohi [1 ]
Fomda, Bashir Ahmad [1 ]
Koul, Parvaiz A. [1 ]
机构：
[1] Sherikashmir Inst Med Sci, Dept Internal Med, Srinagar 190010, Jammu & Kashmir, India
来源：
CURRENT RESPIRATORY MEDICINE REVIEWS | 2018年 / 14卷 / 01期
关键词：
Hospital acquired; mortality; pneumonia; procalcitonin; respiratory tract infection; ventilator associated pneumonia;
D O I：
10.2174/1573398X14666180601073756
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Procalcitonin was introduced to management of hospital-acquired pneumonia/ventilator-associated pneumonia (HAP/VAP) by the American Thoracic Society/Infectious Disease Society of America (ATS/IDSA), in its 2005 HAP guidelines. It was based on the assumption that positive procalcitonin (PCT) results indicative of HAP/VAP of bacterial aetiology will prompt antibiotic therapy, and improve clinical outcomes. Antibiotic stewardship by monitoring of PCT kinetics resulted in shorter antibiotic treatment durations with early cessation of therapies. The diagnostic part is no more recommended due to weak evidence from studies. Beyond diagnostic uses, some studies have shown that positive PCT levels are associated with poorer clinical outcomes in HAP/VAP, Healthcare-associated pneumonia and community-acquired pneumonia. The article will discuss the diagnostic role briefly and mainly the role as a prognostic indicator in the management of HAP/VAP.
引用
收藏
页码：42 / 47
页数：6
相关论文
共 62 条
  • [1] Interleukin-6 and procalcitonin as biomarkers in mortality prediction of hospitalized patients with community acquired pneumonia
    Andrijevic, Ilija
    Matijasevic, Jovan
    Andrijevic, Ljiljana
    Kovacevic, Tomi
    Zaric, Bojan
    [J]. ANNALS OF THORACIC MEDICINE, 2014, 9 (03) : 162 - 167
  • [2] Guidelines for the management, of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia
    不详
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (04) : 388 - 416
  • [3] HIGH SERUM PROCALCITONIN CONCENTRATIONS IN PATIENTS WITH SEPSIS AND INFECTION
    ASSICOT, M
    GENDREL, D
    CARSIN, H
    RAYMOND, J
    GUILBAUD, J
    BOHUON, C
    [J]. LANCET, 1993, 341 (8844) : 515 - 518
  • [4] Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study
    Bloos, Frank
    Marshall, John C.
    Dellinger, Richard P.
    Vincent, Jean-Louis
    Gutierrez, Guillermo
    Rivers, Emanuel
    Balk, Robert A.
    Laterre, Pierre-Francois
    Angus, Derek C.
    Reinhart, Konrad
    Brunkhorst, Frank M.
    [J]. CRITICAL CARE, 2011, 15 (02)
  • [5] Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
    Bouadma, Lila
    Luyt, Charles-Edouard
    Tubach, Florence
    Cracco, Christophe
    Alvarez, Antonio
    Schwebel, Carole
    Schortgen, Frederique
    Lasocki, Sigismond
    Veber, Benoit
    Dehoux, Monique
    Bernard, Maguy
    Pasquet, Blandine
    Regnier, Bernard
    Brun-Buisson, Christian
    Chastre, Jean
    Wolff, Michel
    [J]. LANCET, 2010, 375 (9713) : 463 - 474
  • [6] Diagnostic and prognostic values of admission procalcitonin levels in community-acquired pneumonia in an intensive care unit
    Boussekey, N
    Leroy, O
    Georges, H
    Devos, P
    d'Escrivan, T
    Guery, B
    [J]. INFECTION, 2005, 33 (04) : 257 - 263
  • [7] Christ-Crain M, 2005, SWISS MED WKLY, V135, P451
  • [8] Diagnostic Utility of Plasma Procalcitonin for Nosocomial Pneumonia in the Intensive Care Unit Setting
    Dallas, John
    Brown, Sarah M.
    Hock, Karl
    Scott, Mitchell G.
    Slcrupky, Lee P.
    Boyle, Walter A., III
    Kollef, Marin H.
    [J]. RESPIRATORY CARE, 2011, 56 (04) : 412 - 419
  • [9] Alveolar and serum procalcitonin - Diagnostic and prognostic value in ventilator-associated pneumonia
    Duflo, F
    Debon, R
    Monneret, G
    Bienvenu, J
    Chassard, D
    Allaouchiche, B
    [J]. ANESTHESIOLOGY, 2002, 96 (01) : 74 - 79
  • [10] Prognostic value of procalcitonin in Legionella pneumonia
    Haeuptle, J.
    Zaborsky, R.
    Fiumefreddo, R.
    Trampuz, A.
    Steffen, I.
    Frei, R.
    Christ-Crain, M.
    Mueller, B.
    Schuetz, P.
    [J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2009, 28 (01) : 55 - 60
1234567