INTERACTIONS OF THE NEUROTOXIC AMINE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE WITH MONOAMINE OXIDASES

被引：91
作者：
SINGER, TP
SALACH, JI
CASTAGNOLI, N
TREVOR, A
机构：
[1] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT PHARMACOL,SAN FRANCISCO,CA 94143
[3] VET ADM MED CTR,DIV MOLEC BIOL,SAN FRANCISCO,CA 94121
来源：
BIOCHEMICAL JOURNAL | 1986年 / 235卷 / 03期
关键词：
D O I：
10.1042/bj2350785
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：785 / 789
页数：5
相关论文
共 28 条
[1]  
BLASCHKO H, 1963, ENZYMES, V8, P337
[2]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[3]   ETIOLOGY OF PARKINSONS-DISEASE [J].
CALNE, DB ;
LANGSTON, JW .
LANCET, 1983, 2 (8365) :1457-1459
[4]   POTENTIAL BIOACTIVATION PATHWAYS FOR THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) [J].
CASTAGNOLI, N ;
CHIBA, K ;
TREVOR, AJ .
LIFE SCIENCES, 1985, 36 (03) :225-230
[5]   METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].
CHIBA, K ;
TREVOR, A ;
CASTAGNOLI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578
[6]   ACTIVE UPTAKE OF MPP+, A METABOLITE OF MPTP, BY BRAIN SYNAPTOSOMES [J].
CHIBA, K ;
TREVOR, AJ ;
CASTAGNOLI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 128 (03) :1228-1232
[7]  
CHIBA K, 1985, DRUG METAB DISPOS, V13, P343
[8]  
FULLER RW, 1985, J PHARMACOL EXP THER, V232, P696
[9]  
GHISLA S, 1973, LIEBIGS ANN CHEM, P1388
[10]  
HEIKKILA RE, 1984, NATURE, V311, P467, DOI 10.1038/311467a0
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