BLOCKADE OF T-LYMPHOCYTE AND B-LYMPHOCYTE DEVELOPMENT BY ANTIBODY TO THE GAMMA(C) SUBUNIT OF THE RECEPTORS FOR INTERLEUKIN-2, INTERLEUKIN-4, AND INTERLEUKIN-7

被引:13
|
作者
HE, YW [1 ]
LEVY, RB [1 ]
MALEK, TR [1 ]
机构
[1] UNIV MIAMI,SCH MED,DEPT MICROBIOL & IMMUNOL,MIAMI,FL 33136
关键词
HEMATOPOIESIS; CYTOKINES; SEVERE COMBINED IMMUNODEFICIENCY;
D O I
10.1073/pnas.92.12.5689
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cytokines are important regulators of hematopoesis. Mutations in gamma(c), which is a subunit shared by the receptors for interleukin (IL) 2, IL-4, and IL-7, have been causally associated with human X chromosome-linked severe combined immunodeficiency disease, This finding indicates a mandatory role for cytokine receptor signaling at one or more stages of lymphocyte development. To evaluate the cellular level at which gamma(c) is critical for lymphopoiesis, the effect of monoclonal antibodies to gamma(c) on the capacity of syngeneic bone marrow cells to reconstitute the hematopoietic compartment of lethally irradiated recipient mice was examined, We show that monoclonal antibody to gamma(c) blocked lymphocyte development at or before the appearance of pro-B cells and prior to or at the seeding of the thymus by precursor cells white erythromyeloid cell development was normal, These results suggest that one level of lymphocyte development that requires gamma(c) is a point in hematopoietic cell differentiation near the divergence of lymphopoiesis and erythromyelopoesis.
引用
收藏
页码:5689 / 5693
页数:5
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