USE OF TESTOSTERONE OINTMENT BEFORE HYPOSPADIAS REPAIR

被引：22

作者：

SAKAKIBARA, N

NONOMURA, K

KOYANAGI, T

IMANAKA, K

机构：

[1] Department of Urology, Hokkaido University School of Medicine, Sapporo

来源：

UROLOGIA INTERNATIONALIS | 1991年 / 47卷 / 01期

关键词：

TESTOSTERONE OINTMENT; HYPOSPADIAS REPAIR;

D O I：

10.1159/000282182

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Fifteen children, aged between 2 and 9 years old, with hypospadias (4 penile; 6 penoscrotal; 3 scrotal; 1 perineal) were administered testosterone ointment before one-stage urethroplasty. Temporary penile growth and skin enlargement were obtained in all. Side effects were negligible. The plasma testosterone level was measured before, during and after testosterone administration. During testosterone stimulation, the plasma testosterone level ranged from 30 to 190 ng/dl, and returned to the normal range a week after administration had been stopped. Primary success of hypospadias repair was obtained in 10 of 15 children (66.7%).

引用

页码：40 / 43

页数：4

共 15 条

[1]

Koyanagi T., Matsuno T., Nonomura K., Sakakibara N., Complete repair of severe penoscrotal hypospadias in 1 stage: Experience with urethral mobilization, with flap-flipping urethroplasty and ‘granuloplasty’, J Urol, 130, pp. 1150-1154, (1983)

[2]

Nonomura K., Koyanagi T., Imanaka K., Togashi M., Asano Y., Tanda K., One stage total repair of severe hypospadias with scrotal transposition: Experience in 18 cases, J Pediatr Surg, 23, pp. 177-180, (1988)

[3]

Nonomura K., Koyanagi T., Sakakibara N., A new technique for closure in hypospadias: Ipsilateral penoscrotal approximation for closure, Urol Int, 42, pp. 309-312, (1987)

[4]

Immergut M., Boldus R., Yannone E., Bunge R., Flocks R., The local application of testosterone cream to the prepubatal phallus, J Urol, 105, pp. 905-906, (1971)

[5]

Guthrie R.D., Smith D.W., Graham C.B., Testosterone treatment for micropenis during early childhood, J Pediatr, 83, pp. 247-252, (1973)

[6]

Darby C.W., Vanderschuerren-Lodeweyckx M., Laurence B., Testosterone cream: Use or abuse?, Lancet, 2, (1974)

[7]

Jacobs S., Kaplan G.W., Gittes R.F., Topical testosterone therapy for penile growth, Urology, 6, pp. 708-710, (1975)

[8]

Klugo R., Cerny J.C., Response of micropenis to topical testosterone and gonadotropin, J Urol, 119, pp. 667-668, (1978)

[9]

Burstein S., Grumbach M.M., Kaplan S.L., Early determination of androgen-responsiveness is important in the management of micropenis, Lancet, 2, pp. 983-986, (1979)

[10]

Tsur H., Shafir R., Shachar J., Eshkol A., Microphallic hypospadias: Testosterone therapy prior to surgical repair, J Plast Surg, 36, pp. 398-400, (1983)

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