Homologous recombination maintenance of genome integrity during DNA damage tolerance

被引:22
作者
Prado, Fellix [1 ]
机构
[1] CSIC, CABIMER, Dept Mol Biol, Seville, Spain
来源
MOLECULAR & CELLULAR ONCOLOGY | 2014年 / 1卷 / 02期
关键词
BRCA2; DNA damage tolerance; DNA repair homologous recombination; Rad18; Rad51; replication;
D O I
10.4161/23723548.2014.957039
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The DNA strand exchange protein Rad51 provides a safe mechanism for the repair of DNA breaks using the information of a homologous DNA template. Homologous recombination (HR) also plays a key role in the response to DNA damage that impairs the advance of the replication forks by providing mechanisms to circumvent the lesion and fill in the tracks of single-stranded DNA that are generated during the process of lesion bypass. These activities postpone repair of the blocking lesion to ensure that DNA replication is completed in a timely manner. Experimental evidence generated over the last few years indicates that HR participates in this DNA damage tolerance response together with additional error-free (template switch) and error-prone (translesion synthesis) mechanisms through intricate connections, which are presented here. The choice between repair and tolerance, and the mechanism of tolerance, is critical to avoid increased mutagenesis and/or genome rearrangements, which are both hallmarks of cancer.
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页数:13
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