BRCA2;
DNA damage tolerance;
DNA repair homologous recombination;
Rad18;
Rad51;
replication;
D O I:
10.4161/23723548.2014.957039
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
The DNA strand exchange protein Rad51 provides a safe mechanism for the repair of DNA breaks using the information of a homologous DNA template. Homologous recombination (HR) also plays a key role in the response to DNA damage that impairs the advance of the replication forks by providing mechanisms to circumvent the lesion and fill in the tracks of single-stranded DNA that are generated during the process of lesion bypass. These activities postpone repair of the blocking lesion to ensure that DNA replication is completed in a timely manner. Experimental evidence generated over the last few years indicates that HR participates in this DNA damage tolerance response together with additional error-free (template switch) and error-prone (translesion synthesis) mechanisms through intricate connections, which are presented here. The choice between repair and tolerance, and the mechanism of tolerance, is critical to avoid increased mutagenesis and/or genome rearrangements, which are both hallmarks of cancer.
机构:
Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK, CanadaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Ball, Lindsay G.
Xu, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R ChinaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Xu, Xin
Blackwell, Susan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK, CanadaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Blackwell, Susan
Hanna, Michelle D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK, CanadaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Hanna, Michelle D.
Lambrecht, Amanda D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK, CanadaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Lambrecht, Amanda D.
Xiao, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK, CanadaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
机构:
Univ British Columbia, Michael Smith Labs, Vancouver, BC V5Z 1M9, CanadaNHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA
McManus, Kirk J.
Stoepel, Jan
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Michael Smith Labs, Vancouver, BC V5Z 1M9, CanadaNHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA
Stoepel, Jan
Sipahimalani, Payal
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Michael Smith Labs, Vancouver, BC V5Z 1M9, CanadaNHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA
Sipahimalani, Payal
Godwin, Andrew K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USANHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA
Godwin, Andrew K.
Sgroi, Dennis C.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Mol Pathol Unit, Charlestown, MA USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA USANHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA
机构:
Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK, CanadaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Ball, Lindsay G.
Xu, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R ChinaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Xu, Xin
Blackwell, Susan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK, CanadaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Blackwell, Susan
Hanna, Michelle D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK, CanadaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Hanna, Michelle D.
Lambrecht, Amanda D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK, CanadaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Lambrecht, Amanda D.
Xiao, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK, CanadaCapital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
机构:
Univ British Columbia, Michael Smith Labs, Vancouver, BC V5Z 1M9, CanadaNHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA
McManus, Kirk J.
Stoepel, Jan
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Michael Smith Labs, Vancouver, BC V5Z 1M9, CanadaNHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA
Stoepel, Jan
Sipahimalani, Payal
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Michael Smith Labs, Vancouver, BC V5Z 1M9, CanadaNHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA
Sipahimalani, Payal
Godwin, Andrew K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USANHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA
Godwin, Andrew K.
Sgroi, Dennis C.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Mol Pathol Unit, Charlestown, MA USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA USANHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA