ISOLATION AND STRUCTURE OF STYLOSTATIN-1 FROM THE PAPUA-NEW-GUINEA MARINE SPONGE STYLOTELLA-AURANTIUM

被引:65
作者
PETTIT, GR [1 ]
SRIRANGAM, JK [1 ]
HERALD, DL [1 ]
ERICKSON, KL [1 ]
DOUBEK, DL [1 ]
SCHMIDT, JM [1 ]
TACKETT, LP [1 ]
BAKUS, GJ [1 ]
机构
[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287
关键词
D O I
10.1021/jo00052a041
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new cell growth inhibitory (P388 lymphocytic leukemia ED50 0.8 mug/mL) cycloheptapeptide designated stylostatin 1 (1) has been isolated from the south Pacific Ocean sponge Stylotella aurantium Kelly-Borges and Bergquist. Structural determination was accomplished primarily by utilizing high-field H-1-NMR (500 MHz) with appropriate 2D-NMR experiments and was confirmed by X-ray crystallographic analysis. The absolute configuration (established by chiral gas chromatographic analysis) and crystal structure conformation (with hydrogen bonding) for stylostatin 1 (1) were determined.
引用
收藏
页码:7217 / 7220
页数:4
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