ISOLATION AND STRUCTURE OF STYLOSTATIN-1 FROM THE PAPUA-NEW-GUINEA MARINE SPONGE STYLOTELLA-AURANTIUM

被引：65

作者：

PETTIT, GR ^{[1
]}

SRIRANGAM, JK ^{[1
]}

HERALD, DL ^{[1
]}

ERICKSON, KL ^{[1
]}

DOUBEK, DL ^{[1
]}

SCHMIDT, JM ^{[1
]}

TACKETT, LP ^{[1
]}

BAKUS, GJ ^{[1
]}

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 26期

关键词：

D O I：

10.1021/jo00052a041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new cell growth inhibitory (P388 lymphocytic leukemia ED50 0.8 mug/mL) cycloheptapeptide designated stylostatin 1 (1) has been isolated from the south Pacific Ocean sponge Stylotella aurantium Kelly-Borges and Bergquist. Structural determination was accomplished primarily by utilizing high-field H-1-NMR (500 MHz) with appropriate 2D-NMR experiments and was confirmed by X-ray crystallographic analysis. The absolute configuration (established by chiral gas chromatographic analysis) and crystal structure conformation (with hydrogen bonding) for stylostatin 1 (1) were determined.

引用

页码：7217 / 7220

页数：4

共 12 条

[1] CYTOTOXIC 5-MEMBERED CYCLIC PEROXIDES FROM A PLAKORTIS SPONGE [J].

DAVIDSON, BS .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (23) :6722-6724

[2] DISCODERMIDE - A NEW BIOACTIVE MACROCYCLIC LACTAM FROM THE MARINE SPONGE DISCODERMIA-DISSOLUTA [J].

GUNASEKERA, SP ;

GUNASEKERA, M ;

MCCARTHY, P .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (16) :4830-4833

[3] NIPHATESINES A-D, NEW ANTINEOPLASTIC PYRIDINE ALKALOIDS FROM THE OKINAWAN MARINE SPONGE NIPHATES SP [J].

KOBAYASHI, J ;

MURAYAMA, T ;

KOSUGE, S ;

KANDA, F ;

ISHIBASHI, M ;

KOBAYASHI, H ;

OHIZUMI, Y ;

OHTA, T ;

NOZOE, S ;

SASAKI, T .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (12) :3301-3303

[4] KERAMAMIDE-A, A NOVEL PEPTIDE FROM THE OKINAWAN MARINE SPONGE THEONELLA SP [J].

KOBAYASHI, J ;

SATO, M ;

ISHIBASHI, M ;

SHIGEMORI, H ;

NAKAMURA, T ;

OHIZUMI, Y .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (10) :2609-2611

[5] PATEAMINE - A POTENT CYTOTOXIN FROM THE NEW-ZEALAND MARINE SPONGE, MYCALE SP [J].

NORTHCOTE, PT ;

BLUNT, JW ;

MUNRO, MHG .

TETRAHEDRON LETTERS, 1991, 32 (44) :6411-6414

[6] ANTINEOPLASTIC AGENTS .219. ISOLATION AND STRUCTURE OF THE CELL-GROWTH INHIBITORY CONSTITUENTS FROM THE WESTERN PACIFIC MARINE SPONGE AXINELLA SP [J].

PETTIT, GR ;

HERALD, CL ;

BOYD, MR ;

LEET, JE ;

DUFRESNE, C ;

DOUBEK, DL ;

SCHMIDT, JM ;

CERNY, RL ;

HOOPER, JNA ;

RUTZLER, KC .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (11) :3339-3340

[7] ANTINEOPLASTIC AGENTS .168. ISOLATION AND STRUCTURE OF AXINOHYDANTOIN [J].

PETTIT, GR ;

HERALD, CL ;

LEET, JE ;

GUPTA, R ;

SCHAUFELBERGER, DE ;

BATES, RB ;

CLEWLOW, PJ ;

DOUBEK, DL ;

MANFREDI, KP ;

RUTZLER, K ;

SCHMIDT, JM ;

TACKETT, LP ;

WARD, FB ;

BRUCK, M ;

CAMOU, F .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1990, 68 (09) :1621-1624

[8] ANTINEOPLASTIC AGENTS .193. ISOLATION AND STRUCTURE OF THE CYCLIC PEPTIDE HYMENISTATIN-1 [J].

PETTIT, GR ;

CLEWLOW, PJ ;

DUFRESNE, C ;

DOUBEK, DL ;

CERNY, RL ;

RUTZLER, K .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1990, 68 (05) :708-711

[9]

PETTIT GR, IN PRESS J NAT PROD

[10]

PETTIT GR, 1990, COMP BIOCH PHYSL, P305

← 1 2 →