CONVERSION OF BIALAPHOS TO OTHER OLIGOPEPTIDES CONTAINING PHOSPHINOTHRICIN BY STREPTOMYCES-HYGROSCOPICUS

被引：3

作者：

KUMADA, Y ^{[1
]}

IMAI, S ^{[1
]}

NAGAOKA, K ^{[1
]}

机构：

[1] MEIJI SEIKA KAISHA LTD,PHARMACEUT RES CTR,KOHOKU KU,YOKOHAMA,KANAGAWA 222,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 09期

关键词：

D O I：

10.7164/antibiotics.44.1006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two oligopeptides containing phosphinothricin were accumulated in the culture of bialaphos (BA) producer Streptomyces hygroscopicus SF1293 when large amount of BA was added to the culture at idio phase. One of the oligopeptides was a new substance, BA dimer (phosphinothricyl-alanyl-alanyl-phosphinothricyl-alanyl-alanine), and the other was a known substance called If (phosphinothricyl-alanyl-alanyl-phosphinothricin). Though BA none producing mutants which were blocked at the steps 1, 10 and 13, respectively in BA biosynthesis also converted BA to BA dimer and If, the mutants blocked at the step 11 (alanylation) could not curry out the conversion. Antibiotic activities of BA dimer and If were lower than 1/100 of BA.

引用

页码：1006 / 1012

页数：7

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