DECREASED ATRIAL-NATRIURETIC-PEPTIDE RECEPTORS IN THE ADRENAL-GLAND OF GENETICALLY HYPERTENSIVE RATS

被引：3

作者：

MITTAL, CK

机构：

[1] Division of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, 77004

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1993年 / 6卷 / 05期

关键词：

SPONTANEOUSLY HYPERTENSIVE RATS; ATRIAL NATRIURETIC PEPTIDE; GENETIC HYPERTENSION; ADRENAL GLAND; BLOOD PRESSURE;

D O I：

10.1093/ajh/6.5.431

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

In view of differential effects of atrial natriuretic peptide (ANP) in different models of hypertension, the present study was undertaken to assess ANP receptors in various target organs of spontaneously hypertensive rats (SHRs) and age-matched normotensive Wistar-Kyoto (WKY) rats. Membranes from kidney, thoracic aorta, and adrenal gland were labeled with [I-125]-iodotyrosyl rat atrial peptide (28 amino acid sequence) at 25-degrees-C. Each tissue exhibited uniphasic rectangular hyperbolic saturation isotherm indicative of high affinity single species binding sites. While there were no differences in the ANP receptor densities in thoracic aorta and kidney membranes from the two groups, adrenal gland exhibited lower ANP receptors in the SHRs compared to WKY rats. This study suggests that the lower density of ANP receptors in adrenal gland may be one of the underlying contributing factors in genetic hypertension.

引用

页码：431 / 433

页数：3

共 13 条

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