The effect of panel size and damping on the Sound Transmission Loss (TL) of corrugated and fluted (orthotropic) panels is investigated theoretically and experimentally. A new model which includes the effects of panel damping and size is shown to improve the accuracy of theoretical predictions at low frequencies and for smaller panels. It is shown that the influence of panel size is important at low frequencies and the influence of panel damping is important at high frequencies (usually above 500 Hz for typical building panels). Reducing the panel size increases the low frequency TL while adding damping material increases the high frequency TL.