IMMUNOSUPPRESSIVE THERAPY OF FACTOR-8 INHIBITORS

Immunosuppressive therapy was used in 7 hemophiliac and 3 nonhemophiliac patients with factor VIII inhibitors. Permanent disappearance of the inhibitor occurred in 3 hemophiliac and 2 nonhemophiliac patients following treatment with cyclophosphamide and factor VIII. Critical factors influencing the response to therapy may include both the titer and duration of the inhibitor and the degree of intervening factor VIII exposure prior to immunosuppressive therapy. Two severe hemophiliacs with low titer inhibitors that disappeared without specific therapy are also reported.