ANTICONVULSANT PROPERTIES OF D-20443 IN GENETICALLY EPILEPSY-PRONE RATS - PREDICTION OF CLINICAL-RESPONSE

被引：61
作者：
DAILEY, JW [1 ]
CHEONG, JH [1 ]
KO, KH [1 ]
ADAMSCURTIS, LE [1 ]
JOBE, PC [1 ]
机构：
[1] SEOUL NATL UNIV,COLL PHARM,CTR BIOFUNCT MOLEC,POSTECH,SEOUL,SOUTH KOREA
来源：
NEUROSCIENCE LETTERS | 1995年 / 195卷 / 02期
关键词：
ANTIEPILEPTIC DRUGS; GENETICALLY EPILEPSY-PRONE RATS; SOUND-INDUCED SEIZURES; TONIC CLONIC SEIZURES; ABSENCE SEIZURES;
D O I：
10.1016/0304-3940(95)11783-S
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
D-20443 is an experimental antiepileptic drug. Its mechanism of antiepileptic action is unknown. We evaluated the anticonvulsant effectiveness of D-20443 against sound-induced seizures in genetically epilepsy-prone rats (GEPRs). This compound produced anticonvulsant effects against sound-induced seizures in moderate seizure GEPRs (GEPR-3s) at significantly lower doses than in severe seizure GEPRs (GEPR-9s). Based on these data and on the responses of GEPRs to other antiepileptic drugs, we predict that D-20443 will be a broad spectrum antiepileptic agent in humans. That is, we predict that D-20443 will suppress both tonic/clonic and absence seizures in humans.
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页码：77 / 80
页数：4
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