IMMUNOMODULATORY ACTIONS OF 1,25-DIHYDROXYVITAMIN D-3

被引：164

作者：

LEMIRE, JM

机构：

[1] Department of Pediatrics, University of California, San Diego, La Jolla

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1995年 / 53卷 / 1-6期

关键词：

D O I：

10.1016/0960-0760(95)00106-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sterol, 1,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3), has immunosuppressive activity. The hormone inhibits the production of lymphokines (IL-2, IFN-gamma) and monocyte-derived cytokine (IL-12) leading to inhibition of helper T cell subset type 1 (Th-1). When given in vivo, the hormone prevents the development of spontaneous and induced models of autoimmunity. Analogs of 1,25(OH)(2)D-3, with reduced hypercalcemic effects, display an enhanced activity in autoimmunity compared to the sterol and prolong graft survival in experimental transplantation. This paper reviews our understanding of the cellular actions of the hormone and the therapeutic application of 1,25(OH)(2)D-3 and analogs in autoimmunity and transplantation.

引用

页码：599 / 602

页数：4

共 36 条

[1] 1,25-DIHYDROXYVITAMIN-D3 AND THE REGULATION OF MACROPHAGE FUNCTION [J].