GROWTH OF PRIMARY HUMAN ACUTE LYMPHOBLASTIC AND MYELOBLASTIC-LEUKEMIA IN SCID MICE

被引：12
作者：
DELORD, C
CLUTTERBUCK, R
POWLES, R
MORILLA, R
HANBY, A
TITLEY, J
MIN, T
MILLAR, J
机构：
[1] Section of Medicine, Institute of Cancer Research and Royal Marsden Hospital, Surrey and London
[2] Academic Haematology and Cytogenetics, Institute of Cancer Research and Royal Marsden Hospital, Surrey and London
[3] Histopathology Unit ICRF/RCS, London
来源：
LEUKEMIA & LYMPHOMA | 1994年 / 16卷 / 1-2期
关键词：
LEUKEMIA; SCID MICE;
D O I：
10.3109/10428199409114153
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The in vivo growth of 8 human primary acute lymphoblastic (ALL) and 17 primary acute myeloblastic (AML) cell populations was investigated in severe combined immunodeficient (SCID) mice. Bone marrow (BM) or peripheral blood (PB) samples, either fresh or cryopreserved, were implanted i.v. into irradiated SCID mice. The cells from 5/8 patients with ALL resulted in engraftment with systemic proliferation and dissemination leading to morbidity and mortality of the animals within 12-18 weeks from implantation. In contrast, none of the 17 AML samples resulted in sustained engraftment. Four of the 5 engrafted ALL populations have been successfully passaged into fresh recipients and phenotypic and karyotypic characteristics remain unaltered. The data presented indicate that the SCID mouse may be a useful model for studying the pathogenesis of ALL and may also enable the development and investigation of new therapies for this disease.
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页码：157 / 165
页数：9
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