Levodopa/carbidopa intestinal gel: an effective formulation for the management of advanced Parkinson's disease

With disease progression, almost all Parkinson's disease (PD) patients eventually experience motor fluctuations, often posing a significant challenge for patients and caregivers. Majority of these patients end up with complex medication regimens resulting in increased incidence of adverse effects and a poorer quality of life. Treatment options for advanced PD remain limited; thus, providing the optimal treatment for this growing subpopulation of patients continues to be the focus of many drug development efforts. While deep brain stimulation is considered the most significant therapeutic advancement for advanced PD, it remains an expensive and invasive procedure, with its own risks and complications, which limits global applicability to a wider PD population. Levodopa/carbidopa intestinal gel is one option that may offer a therapeutic benefit as significant as that of deep brain stimulation, and to a broader spectrum of PD patients. This article reviews the pharmacological properties, efficacy, safety and tolerability of levodopa/ carbidopa intestinal gel in PD.