TISSUE FACTOR PATHWAY INHIBITOR AND THE CURRENT CONCEPT OF BLOOD-COAGULATION

被引:123
作者
BROZE, GJ
机构
关键词
CASCADE; KUNITZ; HEMOPHILIA; TISSUE FACTOR; TISSUE FACTOR PATHWAY INHIBITOR; REVIEW;
D O I
10.1097/00001721-199506001-00002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Tissue factor pathway inhibitor (TFPI) is a multivalent, Kunitz-type plasma proteinase inhibitor that regulates tissue factor-induced coagulation. TFPI directly inhibits activated factor X and, in a factor Xa-dependent manner, produces feedback inhibition of the factor VIIa/tissue factor catalytic complex. The properties of this inhibitor help explain the clinical need for 'extrinsic' and 'intrinsic' coagulation pathways and have led to a reformulation of the coagulation cascade. In the revised hypothesis, factor VIIa/tissue factor is responsible for the initiation of coagulation but, owing to TFPI-mediated feedback inhibition, amplification of the procoagulant response though the actions of factor VIII, IX and XI is required for sustained haemostasis.
引用
收藏
页码:S7 / S13
页数:7
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