STRUCTURE AND CHROMOSOMAL MAPPING OF GENES FOR THE MOUSE KAPPA-OPIOID RECEPTOR AND AN OPIOID RECEPTOR HOMOLOG (MOR-C)

被引：98
作者：
NISHI, M
TAKESHIMA, H
MORI, M
NAKAGAWARA, K
TAKEUCHI, T
机构：
[1] TOKYO INST PSYCHIAT,DEPT NEUROCHEM,SETAGAYA KU,TOKYO 156,JAPAN
[2] CLUSTER CORE INC,SENDAI,MIYAGI 983,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 02期
关键词：
D O I：
10.1006/bbrc.1994.2814
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent cDNA cloning studies have defined four members of the opioid receptor family, i.e., delta-, mu- and kappa-subtypes, and an opioid receptor homologue for unknown ligands. In this report, we isolated and analyzed mouse genomic DNA segments containing the kappa-opioid receptor gene and a gene for the opioid receptor homologue (designated as MOR-C). The genes are closely related each other in exon-intron organization, suggesting their evolutional relationship. Using in situ hybridization, we show that the kappa-opioid receptor gene and the MOR-C gene map to mouse chromosome 1A2-3 and 2H2-4, respectively.
引用
收藏
页码：1353 / 1357
页数：5
相关论文
共 22 条
[1]  
AKIL H, 1993, P NATL ACAD SCI USA, V90, P9954
[2]   REGIONAL EXPRESSION AND CHROMOSOMAL LOCALIZATION OF THE DELTA-OPIATE RECEPTOR GENE [J].
BZDEGA, T ;
CHIN, HM ;
KIM, H ;
JUNG, HH ;
KOZAK, CA ;
KLEE, WA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (20) :9305-9309
[3]  
CHEN Y, 1993, MOL PHARMACOL, V44, P8
[4]   MOLECULAR-CLONING OF A RAT KAPPA-OPIOID RECEPTOR REVEALS SEQUENCE SIMILARITIES TO THE MU-OPIOID AND DELTA-OPIOID RECEPTORS [J].
CHEN, Y ;
MESTEK, A ;
LIU, J ;
YU, L .
BIOCHEMICAL JOURNAL, 1993, 295 :625-628
[5]   MOLECULAR-CLONING, TISSUE DISTRIBUTION AND CHROMOSOMAL LOCALIZATION OF A NOVEL MEMBER OF THE OPIOID RECEPTOR GENE FAMILY [J].
CHEN, Y ;
FAN, Y ;
LIU, J ;
MESTEK, A ;
TIAN, MT ;
KOZAK, CA ;
YU, L .
FEBS LETTERS, 1994, 347 (2-3) :279-283
[6]   CLONING OF A DELTA OPIOID RECEPTOR BY FUNCTIONAL EXPRESSION [J].
EVANS, CJ ;
KEITH, DE ;
MORRISON, H ;
MAGENDZO, K ;
EDWARDS, RH .
SCIENCE, 1992, 258 (5090) :1952-1955
[7]   PRIMARY STRUCTURES AND EXPRESSION FROM CDNAS OF RAT OPIOID RECEPTOR DELTA-SUBTYPES AND MU-SUBTYPES [J].
FUKUDA, K ;
KATO, S ;
MORI, K ;
NISHI, M ;
TAKESHIMA, H .
FEBS LETTERS, 1993, 327 (03) :311-314
[8]   CDNA CLONING AND REGIONAL DISTRIBUTION OF A NOVEL MEMBER OF THE OPIOID RECEPTOR FAMILY [J].
FUKUDA, K ;
KATO, S ;
MORI, K ;
NISHI, M ;
TAKESHIMA, H ;
IWABE, N ;
MIYATA, T ;
HOUTANI, T ;
SUGIMOTO, T .
FEBS LETTERS, 1994, 343 (01) :42-46
[9]   WHY GENES IN PIECES [J].
GILBERT, W .
NATURE, 1978, 271 (5645) :501-501
[10]   THE DELTA-OPIOID RECEPTOR - ISOLATION OF A CDNA BY EXPRESSION CLONING AND PHARMACOLOGICAL CHARACTERIZATION [J].
KIEFFER, BL ;
BEFORT, K ;
GAVERIAUXRUFF, C ;
HIRTH, CG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :12048-12052
123