LOCOMOTOR-ACTIVITY FOLLOWING INTRAACCUMBENS MICROINJECTIONS OF DOPAMINE D(1) AGONIST SK-AND-F-38393 IN RATS

被引：33

作者：

MEYER, ME

VANHARTESVELDT, C

POTTER, TJ

机构：

[1] Department of Psychology, University of Florida, Gainesville, Florida

来源：

SYNAPSE | 1993年 / 13卷 / 04期

关键词：

DOPAMINE D(1) AGONIST; LOCOMOTOR ACTIVITY; REARING; STEREOTYPY BEHAVIORS; NUCLEUS ACCUMBENS; SK-AND-F-38393;

D O I：

10.1002/syn.890130403

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the effects of the dopamine D1 receptor subtypes agonist SK&F 38393 on locomotor activities after bilateral microinjection (0.00, 0.01, 0.1, 1.0, 10.0 mug) into the nucleus accumbens (Acb). The dose of 0.1 mug elicited the highest response rate across measures of locomotion, rearing and stereotypy behavior. On the other hand, the largest dose of 10.0 mug was associated with significant increase in center time behaviors. The data were supportive of the hypothesis that dose-related locomotor activities elicited by microinjections of SK&F 38393 into the Acb are independently mediated by D1 receptors.

引用

页码：310 / 314

页数：5

共 24 条

[1]

ALLIN R, 1989, BRAIN RES, V501, P1

[2]

ANDERSEN PH, 1986, NEUROBIOLOGY CENTRAL, P73

[3] DOPAMINE D-1 RECEPTOR AGONISTS COMBINED WITH THE SELECTIVE D-2 AGONIST QUINPIROLE FACILITATE THE EXPRESSION OF ORAL STEREOTYPED BEHAVIOR IN RATS [J].