DOSE PROPORTIONALITY STUDY OF LOPERAMIDE FOLLOWING ORAL-ADMINISTRATION OF LOPERAMIDE OXIDE

被引：0

作者：

KAMALI, F

ADRIAENS, L

HUANG, ML

WOESTENBORGHS, R

EMANUEL, M

RAWLINS, MD

机构：

[1] JANSSEN PHARMACEUT,B-2340 BEERSE,BELGIUM

[2] JANSSEN PHARMACEUT,WANTAGE,ENGLAND

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 42卷 / 06期

关键词：

LOPERAMIDE; LOPERAMIDE OXIDE; DIARRHEA; PHARMACOKINETICS; DOSE-PROPORTIONALITY;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.

引用

页码：693 / 694

页数：2