Investigation of the impurities found in methamphetamine synthesised from pseudoephedrine by reduction with hydriodic acid and red phosphorus

被引：45

作者：

Windahl, KL

McTigue, MJ

Pearson, JR

Pratt, SJ

Rowe, JE

Sear, EM

机构：

[1] LA TROBE UNIV,SCH CHEM,BUNDOORA,VIC 3083,AUSTRALIA

[2] VICTORIA FORENS SCI CTR,MACLEOD,VIC 3085,AUSTRALIA

来源：

FORENSIC SCIENCE INTERNATIONAL | 1995年 / 76卷 / 02期

关键词：

methamphetamine; ephedrine; hydriodic acid/red phosphorus; reduction; impurities; chromatographic analysis; mass spectrometry; NMR spectroscopy;

D O I：

10.1016/0379-0738(95)01803-4

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The synthesis of methamphetamine from pseudoephedrine via the reduction with hydriodic acid and red phosphorus was studied and the impurities which were generated, along with the methamphetamine, were investigated. Some of the impurities found have been reported previously, while the diastereoisomers of N-methyl-N-(alpha-methylphenethyl)amino-1-phenyl-2-propanone and the cis-cinnamoyl derivative of methamphetamine are reported here for the first time. Further work on the sequence of reactions occurring in this reduction is also reported.

引用

页码：97 / 114

页数：18

共 14 条

[1] 2-DIMENSIONAL SPECTROSCOPY - APPLICATION TO NUCLEAR MAGNETIC-RESONANCE [J].