ACUTE ANTIHYPERTENSIVE AND RENAL EFFECTS OF ISRADIPINE IN HYPERTENSIVE PATIENTS WITH NORMAL AND REDUCED RENAL-FUNCTION

被引：6

作者：

WITTENBERG, C

ROSENFELD, JB

机构：

[1] Hypertension Clinic, Beilinson Medical Center Petah Tikva, Tel Aviv University Sackler School of Medicine

[2] Hypertension Clinic, Beilinson Medical Center, Petah Tikva

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 02期

关键词：

HYPERTENSION; ISRADIPINE; RENAL FUNCTION;

D O I：

10.1093/ajh/4.2.191S

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The renal effects of a single oral dose of placebo v a new dihydropyridine calcium antagonist, isradipine, were investigated in 12 patients with mild-to-moderate essential hypertension. Six patients (group A) had normal creatinine concentrations and a further six (group B) had creatinine concentrations > 1.6 mg/dL. Patients maintained a constant daily intake of approximately 120 mmol of sodium and 50 mmol of potassium. Measurements were taken at 30, 60, and 90 min after drug adminstration. Results indicated that isradipine at a dose of 5 mg once daily produced significant antihypertensive and renal responses. In conclusion, there is therapeutic benefit with isradipine independent of the status of renal function.

引用

页码：S191 / S193

页数：3

共 11 条

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