Extracellular/circulating microRNAs and their potential role in cardiovascular disease

被引:4
作者
Zhu, Hongyan [1 ]
Fan, Guo-Chang [1 ]
机构
[1] Univ Cincinnati, Coll Med, Dept Pharmacol & Cell Biophys, 231 Albert Sabin Way, Cincinnati, OH 45267 USA
来源
AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE | 2011年 / 1卷 / 02期
关键词
microRNA; Extracellular; Biomarker; Paracrine; Intercellular communication;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
microRNAs (miRs, miRNAs) are small non-coding RNAs that regulate hundreds of gene expression. Numerous studies have demonstrated that miRNAs are not only found intracellularly, but also detectable outside cells, including various body fluids (i.e. serum, plasma, saliva, urine, breast milk, and tears). Interestingly, similar to 90% of extracellular miRNAs are packaged with proteins (i.e. Ago2, HDL, and other RNA-binding proteins) and similar to 10% are wrapped in small membranous particles (i.e. exosomes, microvesicles, and apoptotic bodies). It is believed that these extracellular miRNAs mediate cell-to-cell communication. Recent studies further indicated that the level and composition of these extracellular/ circulating miRNAs correlated well with disease or injurious conditions. Uncovering the potential role of extracellular miRNAs in the heart is just emerging. This review will highlight recent exciting findings in the regulation of miRNA biogenesis and secretion, their functional roles in paracrine signaling, and the potential as noninvasive biomarkers for cardiovascular disease.
引用
收藏
页码:138 / 149
页数:12
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