共 94 条
Extracellular/circulating microRNAs and their potential role in cardiovascular disease
被引:4
作者:

Zhu, Hongyan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cincinnati, Coll Med, Dept Pharmacol & Cell Biophys, 231 Albert Sabin Way, Cincinnati, OH 45267 USA Univ Cincinnati, Coll Med, Dept Pharmacol & Cell Biophys, 231 Albert Sabin Way, Cincinnati, OH 45267 USA

Fan, Guo-Chang
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cincinnati, Coll Med, Dept Pharmacol & Cell Biophys, 231 Albert Sabin Way, Cincinnati, OH 45267 USA Univ Cincinnati, Coll Med, Dept Pharmacol & Cell Biophys, 231 Albert Sabin Way, Cincinnati, OH 45267 USA
机构:
[1] Univ Cincinnati, Coll Med, Dept Pharmacol & Cell Biophys, 231 Albert Sabin Way, Cincinnati, OH 45267 USA
来源:
AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE
|
2011年
/
1卷
/
02期
关键词:
microRNA;
Extracellular;
Biomarker;
Paracrine;
Intercellular communication;
D O I:
暂无
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
microRNAs (miRs, miRNAs) are small non-coding RNAs that regulate hundreds of gene expression. Numerous studies have demonstrated that miRNAs are not only found intracellularly, but also detectable outside cells, including various body fluids (i.e. serum, plasma, saliva, urine, breast milk, and tears). Interestingly, similar to 90% of extracellular miRNAs are packaged with proteins (i.e. Ago2, HDL, and other RNA-binding proteins) and similar to 10% are wrapped in small membranous particles (i.e. exosomes, microvesicles, and apoptotic bodies). It is believed that these extracellular miRNAs mediate cell-to-cell communication. Recent studies further indicated that the level and composition of these extracellular/ circulating miRNAs correlated well with disease or injurious conditions. Uncovering the potential role of extracellular miRNAs in the heart is just emerging. This review will highlight recent exciting findings in the regulation of miRNA biogenesis and secretion, their functional roles in paracrine signaling, and the potential as noninvasive biomarkers for cardiovascular disease.
引用
收藏
页码:138 / 149
页数:12
相关论文
共 94 条
[1]
Plasma MicroRNA 499 as a Biomarker of Acute Myocardial Infarction
[J].
Adachi, Taichi
;
Nakanishi, Michio
;
Otsuka, Yoritaka
;
Nishimura, Kunihiro
;
Hirokawa, Gou
;
Goto, Yoichi
;
Nonogi, Hiroshi
;
Iwai, Naoharu
.
CLINICAL CHEMISTRY,
2010, 56 (07)
:1183-1185

Adachi, Taichi
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cardiovasc Ctr, Dept Cardiol, Osaka 5658565, Japan Natl Cardiovasc Ctr, Dept Epidemiol, Osaka 5658565, Japan

Nakanishi, Michio
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cardiovasc Ctr, Dept Cardiol, Osaka 5658565, Japan Natl Cardiovasc Ctr, Dept Epidemiol, Osaka 5658565, Japan

Otsuka, Yoritaka
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cardiovasc Ctr, Dept Cardiol, Osaka 5658565, Japan Natl Cardiovasc Ctr, Dept Epidemiol, Osaka 5658565, Japan

Nishimura, Kunihiro
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cardiovasc Ctr, Dept Epidemiol, Osaka 5658565, Japan Natl Cardiovasc Ctr, Dept Epidemiol, Osaka 5658565, Japan

Hirokawa, Gou
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cardiovasc Ctr, Dept Epidemiol, Osaka 5658565, Japan Natl Cardiovasc Ctr, Dept Epidemiol, Osaka 5658565, Japan

Goto, Yoichi
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cardiovasc Ctr, Dept Cardiol, Osaka 5658565, Japan Natl Cardiovasc Ctr, Dept Epidemiol, Osaka 5658565, Japan

Nonogi, Hiroshi
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cardiovasc Ctr, Dept Cardiol, Osaka 5658565, Japan Natl Cardiovasc Ctr, Dept Epidemiol, Osaka 5658565, Japan

Iwai, Naoharu
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Cardiovasc Ctr, Dept Epidemiol, Osaka 5658565, Japan
Natl Cardiovasc Ctr, Dept Cardiol, Osaka 5658565, Japan Natl Cardiovasc Ctr, Dept Epidemiol, Osaka 5658565, Japan
[2]
Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction
[J].
Ai, Jing
;
Zhang, Rong
;
Li, Yue
;
Pu, Jielin
;
Lu, Yanjie
;
Jiao, Jundong
;
Li, Kang
;
Yu, Bo
;
Li, Zhuqin
;
Wang, Rongrong
;
Wang, Lihong
;
Li, Qiang
;
Wang, Nina
;
Shan, Hongli
;
Li, Zhongyu
;
Yang, Baofeng
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
2010, 391 (01)
:73-77

论文数: 引用数:
h-index:
机构:

Zhang, Rong
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Li, Yue
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Pu, Jielin
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
Peking Univ, Coll Med, Beijing 100037, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Lu, Yanjie
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China
Harbin Med Coll, State Prov Key Lab Biomed & Pharmaceut, Harbin 150081, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Jiao, Jundong
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Affiliated Hosp 2, Dept Nephrol, Harbin 150086, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Li, Kang
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Dept Biostat, Harbin 150081, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Yu, Bo
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Affiliated Hosp 2, Dept Cardiol, Harbin 150086, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Li, Zhuqin
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Wang, Rongrong
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
Peking Univ, Coll Med, Beijing 100037, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Wang, Lihong
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Affiliated Hosp 2, Dept Endocrinol & Metab, Harbin 150086, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Li, Qiang
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Affiliated Hosp 2, Dept Endocrinol & Metab, Harbin 150086, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Wang, Nina
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Shan, Hongli
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Li, Zhongyu
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

Yang, Baofeng
论文数: 0 引用数: 0
h-index: 0
机构:
Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China
Harbin Med Coll, State Prov Key Lab Biomed & Pharmaceut, Harbin 150081, Peoples R China Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China
[3]
Microvesicle-mediated RNA Molecule Delivery System Using Monocytes/Macrophages
[J].
Akao, Yukihiro
;
Iio, Akio
;
Itoh, Tomohiro
;
Noguchi, Shunsuke
;
Itoh, Yuko
;
Ohtsuki, Yoshinori
;
Naoe, Tomoki
.
MOLECULAR THERAPY,
2011, 19 (02)
:395-399

Akao, Yukihiro
论文数: 0 引用数: 0
h-index: 0
机构:
Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011193, Japan Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011193, Japan

Iio, Akio
论文数: 0 引用数: 0
h-index: 0
机构:
Gifu Int Inst Biotechnol, Dept Med Oncol, Gifu, Japan Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011193, Japan

Itoh, Tomohiro
论文数: 0 引用数: 0
h-index: 0
机构:
Gifu Int Inst Biotechnol, Dept Med Oncol, Gifu, Japan Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011193, Japan

Noguchi, Shunsuke
论文数: 0 引用数: 0
h-index: 0
机构:
Gifu Univ, United Grad Sch Vet Sci, Gifu 5011193, Japan Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011193, Japan

Itoh, Yuko
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Med Coll, Dept Anat & Cell Biol, Osaka, Japan Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011193, Japan

Ohtsuki, Yoshinori
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Med Coll, Dept Anat & Cell Biol, Osaka, Japan Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011193, Japan

Naoe, Tomoki
论文数: 0 引用数: 0
h-index: 0
机构:
Nagoya Univ, Grad Sch Med, Dept Hematol & Oncol, Nagoya, Aichi 4648601, Japan Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, Gifu 5011193, Japan
[4]
microRNAs: Tiny regulators with great potential
[J].
Ambros, V
.
CELL,
2001, 107 (07)
:823-826

Ambros, V
论文数: 0 引用数: 0
h-index: 0
机构:
Dartmouth Coll Sch Med, Dept Genet, Hanover, NH 03755 USA Dartmouth Coll Sch Med, Dept Genet, Hanover, NH 03755 USA
[5]
Role of extracellular membrane vesicles in the pathogenesis of various diseases, including cancer, renal diseases, atherosclerosis, and arthritis
[J].
Anderson, H. Clarke
;
Mulhall, Douglas
;
Garimella, Rama
.
LABORATORY INVESTIGATION,
2010, 90 (11)
:1549-1557

Anderson, H. Clarke
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66160 USA Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66160 USA

Mulhall, Douglas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ British Columbia, Div Infect Dis, Vancouver, BC V5Z 1M9, Canada
Erasmus Univ, DRIFT Inst, Rotterdam, Netherlands Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66160 USA

Garimella, Rama
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kansas, Med Ctr, Dept Dietet & Nutr Primary, Kansas City, KS 66160 USA
Univ Kansas, Med Ctr, Dept Orthoped Surg Secondary, Kansas City, KS 66160 USA
Univ Kansas, Med Ctr, Dept Pathol & Lab Med Secondary, Kansas City, KS 66160 USA Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66160 USA
[6]
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
[J].
Arroyo, Jason D.
;
Chevillet, John R.
;
Kroh, Evan M.
;
Ruf, Ingrid K.
;
Pritchard, Colin C.
;
Gibson, Donald F.
;
Mitchell, Patrick S.
;
Bennett, Christopher F.
;
Pogosova-Agadjanyan, Era L.
;
Stirewalt, Derek L.
;
Tait, Jonathan F.
;
Tewari, Muneesh
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2011, 108 (12)
:5003-5008

Arroyo, Jason D.
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

Chevillet, John R.
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

Kroh, Evan M.
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

Ruf, Ingrid K.
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

Pritchard, Colin C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Lab Med, Med Ctr, Seattle, WA 98195 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

Gibson, Donald F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Lab Med, Med Ctr, Seattle, WA 98195 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

Mitchell, Patrick S.
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

Bennett, Christopher F.
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA
Univ Washington, Mol & Cellular Biol Program, Seattle, WA 98195 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

Pogosova-Agadjanyan, Era L.
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

Stirewalt, Derek L.
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

Tait, Jonathan F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Lab Med, Med Ctr, Seattle, WA 98195 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

Tewari, Muneesh
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA
Fred Hutchinson Canc Res Ctr, Dept Publ Hlth Sci, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA
[7]
The impact of microRNAs on protein output
[J].
Baek, Daehyun
;
Villen, Judit
;
Shin, Chanseok
;
Camargo, Fernando D.
;
Gygi, Steven P.
;
Bartel, David P.
.
NATURE,
2008, 455 (7209)
:64-U38

Baek, Daehyun
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Villen, Judit
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Shin, Chanseok
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Camargo, Fernando D.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Gygi, Steven P.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Bartel, David P.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[8]
MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
[J].
Bartel, David P.
.
CELL,
2007, 131 (04)
:11-29

Bartel, David P.
论文数: 0 引用数: 0
h-index: 0
机构: Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[9]
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
[J].
Cai, XZ
;
Hagedorn, CH
;
Cullen, BR
.
RNA,
2004, 10 (12)
:1957-1966

Cai, XZ
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

Hagedorn, CH
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

Cullen, BR
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA
[10]
Exosomes/microvesicles as a mechanism of cell-to-cell communication
[J].
Camussi, Giovanni
;
Deregibus, Maria C.
;
Bruno, Stefania
;
Cantaluppi, Vincenzo
;
Biancone, Luigi
.
KIDNEY INTERNATIONAL,
2010, 78 (09)
:838-848

Camussi, Giovanni
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Res Expt Med CeRMS, Turin, Italy
Ctr Mol Biotechnol, Dept Internal Med, Turin, Italy Ctr Res Expt Med CeRMS, Turin, Italy

Deregibus, Maria C.
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Res Expt Med CeRMS, Turin, Italy
Ctr Mol Biotechnol, Dept Internal Med, Turin, Italy Ctr Res Expt Med CeRMS, Turin, Italy

Bruno, Stefania
论文数: 0 引用数: 0
h-index: 0
机构:
Sis Ter, Palazzo, Pignano, Italy Ctr Res Expt Med CeRMS, Turin, Italy

Cantaluppi, Vincenzo
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Res Expt Med CeRMS, Turin, Italy
Ctr Mol Biotechnol, Dept Internal Med, Turin, Italy Ctr Res Expt Med CeRMS, Turin, Italy

Biancone, Luigi
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Res Expt Med CeRMS, Turin, Italy
Ctr Mol Biotechnol, Dept Internal Med, Turin, Italy Ctr Res Expt Med CeRMS, Turin, Italy