POSTHEPARIN LIPOLYTIC-ACTIVITY IN ACUTE AND CHRONIC-RENAL-FAILURE

被引：2

作者：

GUPTA, KL ^{[1
]}

MAJUMDAR, S ^{[1
]}

SAKHUJA, V ^{[1
]}

机构：

[1] POSTGRAD INST MED EDUC & RES,DEPT NEPHROL,CHANDIGARH 160012,INDIA

来源：

RENAL FAILURE | 1994年 / 16卷 / 05期

关键词：

HEPATIC TRIGLYCERIDE LIPASE; LIPOPROTEIN LIPASE; POSTHEPARIN LIPOLYTIC ACTIVITY; RENAL FAILURE;

D O I：

10.3109/08860229409044888

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Lipid profile and postheparin lipolytic activity (PHLA) were investigated in 21 patients with acute renal failure (ARF), 24 with chronic renal failure (CRF), and 23 healthy volunteers. Plasma triglycerides were significantly elevated in ARF (155.19 +/- 72.39 mg/dL) as well as CRF (166.79 +/- 72.36 mg/dL), as compared to controls (89.91 +/- 23.41 mg/dL, p < .001). PHLA was determined at 5, 10, 30, and 60 min after intravenous heparin (100 U/kg) and was observed to be reduced in ARF (7.82 +/- 1.41 mu mol FFA/mL/h) as well as CRF (8.44 +/- 1.68 mu mol FFA/mL/h) at 10 min, as compared to the values in the control subjects (12.03 +/- 2.43 mu mol FFA/mL/h, p < .01). No correlation was found between PHLA and plasma triglycerides in ARF or CRF. In 15 patients in each group, PHLA subfractions, hepatic triglyceride lipase (HTGL), and lipoprotein lipase (LPL) were determined at similar time intervals after hepa;in. Both fractions were found to be reduced significantly (p < .01) in ARF as well as in CRF versus controls. These findings indicate that the lipid alterations in acute and chronic renal failure share common features including hypertriglyceridemia and reduced PHLA and its subfractions HTGL and LPL.

引用

页码：609 / 615

页数：7

共 24 条

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