DETERMINATION OF AMPHETAMINE AND METHAMPHETAMINE IN URINE WITH SODIUM 1,2-NAPHTHOQUINONE 4-SULFONATE USING THE H-POINT STANDARD ADDITION METHOD

被引：9
作者：
FALCO, PC
REIG, FB
CABEZA, AS
LEGUA, CM
机构：
[1] Departamento de Química Analítica, Universidad de Valencia, 46100 Burjassot, Valencia
来源：
ANALYTICA CHIMICA ACTA | 1994年 / 287卷 / 1-2期
关键词：
UV-VISIBLE SPECTROPHOTOMETRY; AMPHETAMINE; EXTRACTION; H-POINT STANDARD ADDITION METHOD; METHAMPHETAMINE; PHARMACEUTICALS; URINE;
D O I：
10.1016/0003-2670(94)85099-2
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The determination of amphetamine and methamphetamine in urine by the H-point standard additions method (HPSAM) is described. An extraction-spectrophotometric method for the determination of these drugs with sodium 1,2-naphthoquinone 4-sulphonate using n-hexane-ethyl acetate (1:1) as the extraction solvent is proposed. The analytes are previously extracted into n-hexane. Although their spectra are very similar and overlap, the H-point standard additions method provides good results for both amines. The applicability of the method when the total Youden blank is present is demonstrated. The relative errors found were less than 10%.
引用
收藏
页码：41 / 48
页数：8
相关论文
共 31 条
[11]  
FOLTZ RL, 1980, NATIONAL I DRUG ABUS, V32
[12]   DETERMINATION OF SOME DOPING AGENTS BY OVERPRESSURED THIN-LAYER CHROMATOGRAPHY [J].
GULYAS, H ;
KEMENY, G ;
HOLLOSI, I ;
PUCSOK, J .
JOURNAL OF CHROMATOGRAPHY, 1984, 291 (MAY) :471-475
[13]  
GURKAN T, 1976, MIKROCHIM ACTA, V1, P165
[14]  
GURKAN T, 1980, J FAC PHARM ISTAMBUL, V16, P73
[15]  
HASHIMOTO Y, 1978, MIKROCHIM ACTA, V2, P493
[16]   QUANTITATION OF METHAMPHETAMINE AND AMPHETAMINE IN URINE BY CAPILLARY GC MS .1. ADVANTAGES OF TRICHLOROACETYL DERIVATIZATION [J].
HORNBECK, CL ;
CZARNY, RJ .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1989, 13 (03) :144-149
[17]   DETECTION OF AMPHETAMINE AND METHAMPHETAMINE IN URINE BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY FOLLOWING DERIVATIZATION WITH (-)-MENTHYL CHLOROFORMATE [J].
HUGHES, RO ;
BRONNER, WE ;
SMITH, ML .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1991, 15 (05) :256-259
[18]  
LEGUA CM, IN PRESS ANAL CHIM A
[19]   ELECTROCHEMICAL LABEL FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY .1. BETA-NAPHTHOQUINONE-4-SULPHONATE AS AN ELECTROCHEMICAL DETECTION LABELING REAGENT OF AMINES [J].
NAKAHARA, Y ;
ISHIGAMI, A ;
TAKEDA, Y .
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1989, 489 (02) :371-376
[20]   H-POINT STANDARD ADDITIONS METHOD .1. FUNDAMENTALS AND APPLICATION TO ANALYTICAL SPECTROSCOPY [J].
REIG, FB ;
FALCO, PC .
ANALYST, 1988, 113 (07) :1011-1016
1234