P-31 NMR-SPECTROSCOPY - THE NONINVASIVE TOOL FOR THE STUDY OF THE BIOCHEMISTRY OF THE CARDIOVASCULAR-SYSTEM

被引：7
作者：
INGWALL, JS
WEISS, RG
机构：
[1] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
[2] JOHNS HOPKINS UNIV HOSP, DEPT MED, DIV CARDIOL, PETER BELFER LAB, BALTIMORE, MD 21205 USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 1993年 / 3卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/1050-1738(93)90025-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent advances in nuclear magnetic resonance (NMR) spectroscopy have allowed the transition to be made from using animal models for studies of the biochemistry of the cardiovascular system to direct measurements in human myocardium. P-31 NMR spectroscopy is now being used to define changes in the relative concentrations of phosphocreatine and ATP (the abundant high-energy phosphate compounds in muscle) in normal, ischemic, hypertrophied, and failing human hearts. Use of P-31 magnetization transfer to measure turnover of high-energy phosphate-containing compounds provides new insights into myocardial energetics.
引用
收藏
页码：29 / 37
页数：9
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