CHROMATOGRAPHY WITH METAL SPECIFIC DETECTION OF URINE SAMPLES FROM AN ARTHRITIS PATIENT ON AURANOFIN THERAPY

被引：13

作者：

ELDER, RC

TEPPERMAN, K

TARVER, ML

MATZ, S

JONES, WB

HESS, EV

机构：

[1] UNIV CINCINNATI,BIOMED CHEM RES CTR,CINCINNATI,OH 45221

[2] UNIV CINCINNATI,DEPT BIOL SCI,CINCINNATI,OH 45221

[3] UNIV CINCINNATI,DEPT INTERNAL MED,DIV IMMUNOL,CINCINNATI,OH 45221

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1990年 / 13卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/01483919008049242

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Six sequential urine samples obtained from a patient on auranofin therapy were analyzed for total gold, zinc, copper and creatinine levels. They were separated by high performance liquid chromatography (HPLC) on a weak anion exchange column. The detector utilized was an inductively coupled plasma mass spectrometer (ICP-MS). Five, gold-containing metabolites as well as multiple zinc- and copper-containing materials were eluted. The distribution of all three metals changed with time on therapy. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：1191 / 1202

页数：12

共 11 条

[1]

Beard H.H., 1943, CREATINE CREATININE

[2]

BLUHM GB, 1982, J RHEUMATOL, V9, P10

[3] SYNCHROTRON X-RAY STUDIES OF METAL-BASED DRUGS AND METABOLITES [J].