KHUSIMOL, A NONPEPTIDE LIGAND FOR VASOPRESSIN V-1A RECEPTORS

被引：9

作者：

RAO, RC

SERRADEILLEGAL, C

GRANGER, I

GLEYE, J

AUGEREAU, JM

BESSIBES, C

机构：

[1] FAC PHARM TOULOUSE,PHARMACOGNOSIE LAB,F-31400 TOULOUSE,FRANCE

[2] SANOFI ELF BIO RECH,PHYTOTECHNOL LAB,F-31328 LABEGE,FRANCE

[3] ELF AQUITAINE CO,GRP RECH LACQ,F-64170 ARTIX,FRANCE

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 10期

关键词：

D O I：

10.1021/np50112a001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In the course of a random screen of various plant extracts, khusimol [1], a nonpeptide molecule isolated from the root of Vetiveria zizanioides, was found to competitively inhibit the binding of vasopressin to rat liver V-1a receptors (K-i=50 mu M) The H-1- and C-13-nmr spectra of this sesquiterpene alcohol were assigned unambiguously.

引用

页码：1329 / 1335

页数：7

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