ALKYLATION OF NUCLEOSIDES BY DEHYDROMONOCROTALINE, THE PUTATIVE TOXIC METABOLITE OF THE CARCINOGENIC PYRROLIZIDINE ALKALOID MONOCROTALINE

被引：41

作者：

NIWA, H

OGAWA, T

OKAMOTO, O

YAMADA, K

机构：

[1] Department of Chemistry, Faculty of Science, Nagoya University, Chikusa, Nagoya

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(00)92122-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of dehydromonocrotaline (3), the putative toxic metabolite of the carcinogenic pyrrolizidine alkaloid monocrotaline (2), with various nucleosides proceeded mostly at the C-9'' position of 3 to give several nitrogen atom-alkylated nucleosides including N-7 alkylated 2'-deoxyguanosine 14.

引用

页码：927 / 930

页数：4

共 10 条

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