The Structure and Signaling Mechanisms of Type 1 Cytokine Receptors: A Brief Overview

被引:1
作者
Esen, Ihsan [1 ]
机构
[1] Firat Univ, Dept Pediat, Fac Med, Div Pediat Endocrinol, TR-23169 Elazig, Turkey
来源
TURKISH JOURNAL OF IMMUNOLOGY | 2015年 / 3卷 / 03期
关键词
Cytokines; receptors; type 1 cytokine receptors;
D O I
10.5606/tji.2015.377
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cytokines, the secreted messenger molecules, act on their target cells by binding specific membrane receptors. Many cell functions are regulated by members of cytokine receptors mediated intracellular signaling mechanisms. The classification of cytokine receptors is based on structural homologies of extracellular cytokine-binding domains and shared intracellular signaling mechanisms. A simple classification of cytokine receptors contains type 1 cytokine receptors, type 2 cytokine receptors, tumor necrosis factor receptor family, interleukin 1 receptor family, and seven transmembrane G-protein-coupled receptors. This article focuses on the structure and associated signaling pathways of type 1 cytokine receptors.
引用
收藏
页码:121 / 124
页数:4
相关论文
共 21 条
  • [1] Abbas AK, 2012, CELLULAR MOL IMMUNOL, P139
  • [3] Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor
    Brooks, Andrew J.
    Dai, Wei
    O'Mara, Megan L.
    Abankwa, Daniel
    Chhabra, Yash
    Pelekanos, Rebecca A.
    Gardon, Olivier
    Tunny, Kathryn A.
    Blucher, Kristopher M.
    Morton, Craig J.
    Parker, Michael W.
    Sierecki, Emma
    Gambin, Yann
    Gomez, Guillermo A.
    Alexandrov, Kirill
    Wilson, Ian A.
    Doxastakis, Manolis
    Mark, Alan E.
    Waters, Michael J.
    [J]. SCIENCE, 2014, 344 (6185) : 710 - +
  • [4] Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
    Brown, RJ
    Adams, JJ
    Pelekanos, RA
    Wan, Y
    McKinstry, WJ
    Palethorpe, K
    Seeber, RM
    Monks, TA
    Eidne, KA
    Parker, MW
    Waters, MJ
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (09) : 814 - 821
  • [5] A new protein containing an SH2 domain that inhibits JAK kinases
    Endo, TA
    Masuhara, M
    Yokouchi, M
    Suzuki, R
    Sakamoto, H
    Mitsui, K
    Matsumoto, A
    Tanimura, S
    Ohtsubo, M
    Misawa, H
    Miyazaki, T
    Leonor, N
    Taniguchi, T
    Fujita, T
    Kanakura, Y
    Komiya, S
    Yoshimura, A
    [J]. NATURE, 1997, 387 (6636) : 921 - 924
  • [6] Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis
    Gent, J
    van Kerkhof, P
    Roza, M
    Bu, GJ
    Strous, GJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) : 9858 - 9863
  • [7] Signaling pathways activated by the growth hormone receptor
    Herrington, J
    Carter-Su, C
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2001, 12 (06) : 252 - 257
  • [8] Twenty proteins containing a C-terminal SOCS box form five structural classes
    Hilton, DJ
    Richardson, RT
    Alexander, WS
    Viney, EM
    Willson, TA
    Sprigg, NS
    Starr, R
    Nicholson, SE
    Metcalf, D
    Nicola, NA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (01) : 114 - 119
  • [9] MOLECULAR-CLONING OF L-JAK, A JANUS FAMILY PROTEIN-TYROSINE KINASE EXPRESSED IN NATURAL-KILLER-CELLS AND ACTIVATED LEUKOCYTES
    KAWAMURA, M
    MCVICAR, DW
    JOHNSTON, JA
    BLAKE, TB
    CHEN, YQ
    LAL, BK
    LLOYD, AR
    KELVIN, DJ
    STAPLES, JE
    ORTALDO, JR
    OSHEA, JJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) : 6374 - 6378
  • [10] Cytokine receptor signaling pathways
    Leonard, WJ
    Lin, JX
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 105 (05) : 877 - 888