The impact of mathematical modeling on the understanding of diabetes and related complications

被引：83
作者：
Ajmera, I. [1 ,2 ]
Swat, M. [1 ]
Laibe, C. [1 ]
Le Novere, N. [1 ,3 ]
Chelliah, V. [1 ]
机构：
[1] EMBL European Bioinformat Inst, BioModels Grp, Wellcome Trust Genome Campus, Cambridge, England
[2] Univ Nottingham, Sch Biosci, Multidiscipinary Ctr Integrat Biol MyCIB, Loughborough, Leics, England
[3] Babraham Inst, Cambridge, England
来源：
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY | 2013年 / 2卷 / 07期
基金：
英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1038/psp.2013.30
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Diabetes is a chronic and complex multifactorial disease caused by persistent hyperglycemia and for which underlying pathogenesis is still not completely understood. The mathematical modeling of glucose homeostasis, diabetic condition, and its associated complications is rapidly growing and provides new insights into the underlying mechanisms involved. Here, we discuss contributions to the diabetes modeling field over the past five decades, highlighting the areas where more focused research is required.
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页数：14
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