A STUDY OF CARDIOVASCULAR AND ANTIMICROBIAL EFFECTS OF TINOSPORA CORDIFOLIA

被引：0

作者：

Archana, J. ^{[1
]}

Kusuma, M. P. ^{[1
]}

机构：

[1] RBVRR Womens Coll Pharm, Hyderabad 500027, Andhra Prades, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2012年 / 3卷 / 09期

关键词：

Chronotropic; Ionotropic; Isolated frog heart; Agar diffusion assay;

D O I：

10.13040/IJPSR.0975-8232.3(9).3486-89

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tinospora cordifolia is known for a wide range of medicinal properties. In this study, cardiovascular and antimicrobial properties of aqueous and ethanolic extracts of Tinospora cordifolia were evaluated. Dose dependent negative ionotropic and chronotropic effects were observed with both aqueous and ethanolic extracts. The effects were antagonized by atropine indicating involvement of muscarinic receptors. Maximum antimicrobial activity was found with ethanolic extract of Tinospora cordifolia (15mm) against Pseudomonas aeruginosa. The organism showed resistance to aqueous extract giving an inhibition zone of 0.3mm. The data suggest that Tinospora cordifolia could be of benefit in arrhythmias and microbial infections.

引用

页码：3486 / 3489

页数：4