Simulation of enzyme-substrate interactions: The diffusional encounter step

被引：0
作者：
Wade, RC
机构：
来源：
ACTA BIOCHIMICA POLONICA | 1995年 / 42卷 / 04期
关键词：
Brownian-dynamics; diffusion control; electrostatic steering; enzyme-substrate interaction;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Enzymes are targets for structure-based redesign and drug design. One potentially important design strategy is to create molecules - enzymes and ligands - with desired diffusional encounter properties. Rates of diffusive bimolecular encounter can be calculated by Brownian dynamics simulation. This methodology and its application to study the factors influencing the rates of diffusion-influenced enzymes are described here.
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页码：419 / 425
页数：7
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