TRIFLUOROMETHYLATION OF ORGANIC HALIDES WITH METHYL HALODIFLUOROACETATES - A PROCESS VIA DIFLUOROCARBENE AND TRIFLUOROMETHIDE INTERMEDIATES

被引：64

作者：

DUAN, JX ^{[1
]}

SU, DB ^{[1
]}

CHEN, QY ^{[1
]}

机构：

[1] ACAD SINICA,SHANGHAI INST ORGAN CHEM,345 LINGLING LU,SHANGHAI 200032,PEOPLES R CHINA

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1993年 / 61卷 / 03期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0022-1139(00)80112-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Treatment of methyl halodifluoroacetates, XCF2CO2Me (X = Cl, Br, I), with organic halides RY in the presence of KF and CuI at an appropriate temperature in DMF gave the corresponding trifluoromethylated derivatives, RCF3, in moderate to high yields. A process involving difluorocarbene and trifluoromethide intermediates is suggested.

引用

页码：279 / 284

页数：6

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