HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR DIRECT SEPARATION OF 5-(PARA-HYDROXYPHENYL)-5-PHENYLHYDANTOIN ENANTIOMERS USING A CHIRAL TRIS(4-METHYLBENZOATE) COLUMN

被引：18

作者：

ETO, S

NODA, H

NODA, A

机构：

[1] UNIV OCCUPAT & ENVIRONM HLTH,DEPT HOSP PHARM,1-1 ISEIGAOKA,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN

[2] KYUSHU UNIV,FAC PHARMACEUT SCI,FUKUOKA 812,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 568卷 / 01期

关键词：

D O I：

10.1016/0378-4347(91)80349-H

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

After simple purification of the incubation mixture of phenytoin in isolated rat hepatocytes, 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH), which formed as a major metabolite, was readily resolved to each enantiomer by direct high-performance liquid chromatography on a cellulose tris(4-methylbenzoate) column, with a mobile phase of ethanol-water. It was also observed that the formation of S-(-)-p-HPPH was dominant, and the S/R ratio was 11.5.

引用

页码：157 / 163

页数：7

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