NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension

被引：50

作者：

Orlov, Sergei N. ^{[1
,2
]}

Koltsova, Svetlana V. ^{[1
]}

Kapilevich, Leonid V. ^{[2
,3
]}

Gusakova, Svetlana V. ^{[3
]}

Dulin, Nickolai O. ^{[4
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Biol, Moscow, Russia

[2] Tomsk State Univ, Tomsk, Russia

[3] Siberian State Med Univ, Tomsk, Russia

[4] Univ Chicago, Dept Med, Chicago, IL 60637 USA

来源：

GENES & DISEASES | 2015年 / 2卷 / 02期

基金：

美国国家卫生研究院; 俄罗斯科学基金会;

关键词：

Hypertension; Intracellular chloride; Myogenic tone; Neuronal cell; NKCC cotransport; Smooth muscle;

D O I：

10.1016/j.gendis.2015.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review summarizes the data on the functional significance of ubiquitous (NKCC1) and renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride cotransporters. These carriers contribute to the pathogenesis of hypertension via regulation of intracellular chloride concentration in vascular smooth muscle and neuronal cells and via sensing chloride concentration in the renal tubular fluid, respectively. Both NKCC1 and NKCC2 are inhibited by furosemide and other high-ceiling diuretics widely used for attenuation of extracellular fluid volume. However, the chronic usage of these compounds for the treatment of hypertension and other volume-expanded disorders may have diverse side-effects due to suppression of myogenic response in microcirculatory beds. Copyright (C) 2015, Chongqing Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license

引用

页码：186 / 196

页数：11

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