HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC RESOLUTION OF RACEMIC 1,4-BENZODIAZEPIN-2-ONES BY MEANS OF A BETA-CYCLODEXTRIN SILICA BONDED CHIRAL STATIONARY PHASE

被引：25

作者：

BERTUCCI, C

DOMENICI, E

UCCELLOBARRETTA, G

SALVADORI, P

机构：

[1] UNIV PISA,CNR,CTR STUDIO MACROMOLEC STEREORDINATE & OTTICAMENTE ATT,DIPARTIMENTO CHIM & CHIM IND,I-56126 PISA,ITALY

[2] SCUOLA NORMALE SUPER PISA,I-56100 PISA,ITALY

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 506卷

关键词：

D O I：

10.1016/S0021-9673(01)91610-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A bonded β-cyclodextrin chiral stationary phase was used for the chromatographic resolution of a series of 1,4-benzodiazepin-2-ones (BDZs). This column can also be employed for the direct resolution of ionic BDZs as the hemisuccinate esters of 3-hydroxy-BDZs. Nuclear magnetic resonance spectroscopy was used to obtain preliminary information on the mechanism of chiral discrimination. © 1990.

引用

页码：617 / 625

页数：9

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